产品名称

英文名称：Nimodipine

同义词

Nimodipine ap、SPECTRUM1503600、2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate、3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester、DTXCID003370、MLS00、尼莫地平

产品性质

CAS编号：66085-59-4

分子式：C21H26N2O7

分子量：418.44

EC号：266-127-0

MDL号：MFCD00153848

PubChem编号：4497

别名：尼莫地平

英文别名：Nimodipine ap|SPECTRUM1503600|2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate|3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-methoxyethyl 1-methylethyl ester|DTXCID003370|MLS00

规格或纯度：≥98%

英文名称：Nimodipine

生化机理：Nimodipine is an L-type calcium channel protein inhibitor. Nimodipine is an inhibitor of Mdr.L-type Ca 2+ channel blocker. Potent cerebrovasodilator. Cognitive enhancer. More lipophilic than nifedipine.

应用：An L-type calcium channel protein inhibitor

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Nimodipine是一种二氢吡啶衍生物，是钙离子通道抑制剂Nifedipine的类似物，具有降压活性。Nimodipine能减少细胞内游离Ca2+，Beclin-1及细胞自噬An L-type calcium channel protein inhibitorNimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagyAn L-type calcium channel protein inhibitor

IUPAC Name：3-O-(2-methoxyethyl) 5-O-propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

INCHI：InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

InChi Key：UIAGMCDKSXEBJQ-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC

Isomeric SMILES：CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCOC

WGK Germany：1

RTECS：US7975500

PubChem CID：4497

Reaxy-Rn：459792

ChEBI：CHEBI7575

ChEMBL Ligand：CHEMBL1428

DrugBank Ligand：DB00393

BindingDB Ligand：50011690

Wikipedia：Nimodipine

CAS Registry No.：66085-59-4

PEP：nimodipine

DrugCentral Ligand：1937

溶解性：Soluble in methanol (62.5 mg/ml), DMSO (25 mg/ml), dioxane, water (24.3 mg/L) at 25 °C, and ethanol (10 mM). Insoluble in 2-hydroxypropyl-b-cyclodextrin.

熔点：125°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH373 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P302+P352,P321,P405,P501,P264,P260,P362+P364,P203,P318,P332+P317,P319

Merck Index：6551

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装