产品名称

英文名称：Losartan Potassium (DuP 753)

同义词

LOSARTAN POTASSIUM、124750-99-8、ERYTHROPOIETIN、Cozaar、Losacar、Losaprex、Lorzaar、Losata、Tancin、Nu-Lotan、losartan potassium salt、Hyzaar、Losartan monopotassium salt、Aradois、Lifezar、Lortaan、Lorzaan、Losacor、Tenopres、Ocsaar、Lotim、Niten、Zaart、Neo Lotan、DuP 753、Pre、洛沙坦钾、2-丁基-4-氯-1-[[2'-(1H-四唑-5-基)-1,1'-联苯-4-基]甲基]咪唑-5-甲醇钾、2-丁基-4-氯-1-{[2'-(1H-四唑-5-基)(1,1'-联苯)-4-基]甲基}-1H-咪唑-5-甲醇 单钾盐

产品性质

CAS编号：124750-99-8

分子式：C22H22ClKN6O

分子量：461

Beilstein号：5845770

MDL号：MFCD02092704

PubChem编号：11751549

别名：洛沙坦钾|2-丁基-4-氯-1-[[2'-(1H-四唑-5-基)-1,1'-联苯-4-基]甲基]咪唑-5-甲醇钾|2-丁基-4-氯-1-{[2'-(1H-四唑-5-基)(1,1'-联苯)-4-基]甲基}-1H-咪唑-5-甲醇 单钾盐

英文别名：LOSARTAN POTASSIUM|124750-99-8|ERYTHROPOIETIN|Cozaar|Losacar|Losaprex|Lorzaar|Losata|Tancin|Nu-Lotan|losartan potassium salt|Hyzaar|Losartan monopotassium salt|Aradois|Lifezar|Lortaan|Lorzaan|Losacor|Tenopres|Ocsaar|Lotim|Niten|Zaart|Neo Lotan|DuP 753|Pre

规格或纯度：≥99%

英文名称：Losartan Potassium (DuP 753)

生化机理：Losartan Potassium is a specific antagonist of the angiotensin II receptor subtype AT1. Antagonism of the AT1 receptor and interference of association between AT1 and angiotensin II produces vasodilation and reduction of hypertension. This antagonism has other downstream effects, including a correlated antagonism of the thromboxane A2 receptor, inhibition of platelet aggregation, and induction of peroxisome proliferator-actived receptor gamma (PPARγ) activity.Selective non-peptide angiotensin II type 1 (AT 1 ) receptor antagonist (K i = 10 nM). Blocks classical actions of angiotensin II . Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo .

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.A specific antagonist of the AT1 receptor with significant downstream effects.Losartan potassium is a new drug used for hypertension. It is nonpeptide angiotensin II (AII) receptor antagonist.Losartan potassium is nonpeptide angiotensin II (AII) receptor antagonist and is orally active. It belongs to a new class of drugs introduced for clinical trials to treat hypertension.A specific antagonist of the AT1 receptor with significant downstream effects.

IUPAC Name：potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol

INCHI：InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChi Key：OXCMYAYHXIHQOA-UHFFFAOYSA-N

Canonical SMILES：CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

Isomeric SMILES：CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NN=N[N-]4)CO)Cl.[K+]

RTECS：NI6755100

PubChem CID：11751549

Reaxy-Rn：5900704

溶解性：Soluble in water (>500 mg/ml), PBS (pH 7.2) (≥10 mg/ml), ethanol (≥20 mg/ml), DMSO (100 mM), and DMF (≥20 mg/ml).

敏感性：对湿度敏感

熔点：183.5 - 184.5 °C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P330,P263,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P337+P317,P319

Merck Index：5583

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