产品名称

英文名称：Kenpaullone

同义词

kenpaullone、142273-20-9、9-Bromopaullone、NSC 664704、NSC-664704、9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one、9-bromo-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one、Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-、9-Bromopaullone;、肯帕罗酮、NSC 664704、9-溴-7,12-二氢-吲哚并[3,2-d][1]苯并吖庚因-6(5H)-酮、9-溴-7,12-二氢吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮

产品性质

CAS编号：142273-20-9

分子式：C16H11BrN2O

分子量：327.18

MDL号：MFCD02683595

PubChem编号：3820

别名：肯帕罗酮|NSC 664704|9-溴-7,12-二氢-吲哚并[3,2-d][1]苯并吖庚因-6(5H)-酮|9-溴-7,12-二氢吲哚并[3,2-d][1]苯并氮杂卓-6(5H)-酮

英文别名：kenpaullone|142273-20-9|9-Bromopaullone|NSC 664704|NSC-664704|9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one|9-bromo-7,12-dihydrobenzo[2,3]azepino[4,5-b]indol-6(5H)-one|Indolo[3,2-d][1]benzazepin-6(5H)-one, 9-bromo-7,12-dihydro-|9-Bromopaullone;

规格或纯度：>97.0%(HPLC)

英文名称：Kenpaullone

生化机理：Kenpaullone is also an inhibitor of glycogen synthase kinase 3β (GSK3β). It also inhibits cyclin-dependent kinase 1 (CDK1/cyclin B), CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25, majorly by competitive inhibition of adenosine triphosphate (ATP) binding.

应用：A Cdk and GKS-3 inhibitor

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Kenpaullone (9-Bromopaullone, NSC-664704)是CDKs的ATP竞争性抑制剂，它同样也抑制GSK3β，IC50为0.23 μM。Kenpaullone has been used as a glycogen synthase kinase 3 (GSK3)/ cyclin-dependent kinase (CDK) inhibitor to study its effects on human neural progenitor cell lines as an inhibitor of Krupple-like factor 4 (KLF4) in Gs-coupled designer GPCR (Gs DREADD= GsD) Agouti-related peptide (GsD-AgRP) mice as a GSK3/CDK inhibitor to study its effects on the sea urchin embryo development

IUPAC Name：9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one

INCHI：InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)

InChi Key：QQUXFYAWXPMDOE-UHFFFAOYSA-N

Canonical SMILES：C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

Isomeric SMILES：C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br

WGK Germany：3

PubChem CID：3820

ChEMBL Ligand：CHEMBL296586

CAS Registry No.：142273-20-9

Reactome Reaction：R-HSA-9687724

Reactome Drug：R-ALL-9687654

敏感性：对热、空气敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装