产品名称

英文名称：Costundide

同义词

Costunolide、553-21-9、(+)-costunolide、Costunlide、Costunolid、Costus lactone、CHEMBL86416、CHEBI3900、(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one、(E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid

产品性质

CAS编号：553-21-9

分子式：C15H20O2

分子量：232.32

MDL号：MFCD00210262

PubChem编号：5281437

英文别名：Costunolide|553-21-9|(+)-costunolide|Costunlide|Costunolid|Costus lactone|CHEMBL86416|CHEBI3900|(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one|(E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid

规格或纯度：≥97%

英文名称：Costundide

生化机理：DescriptionIC50 Value 6.2 - 9.8 ?g/mL(sarcoma cells viability)[3]Costunolide, a sesquiterpene lactone, exhibits anti-inflammatory and anti-oxidant properties and mediates apoptosis.in vitro Costunolide significantly inhibited RANKL-induced BMM differentiation into osteoclasts in a dose-dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways of RANKL, including the mitogen-activated protein kinase and NF-κB pathways. However, costunolide suppressed nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) expression via inhibition of c-Fos transcriptional activity without affecting RANKL-induced c-Fos expression. The inhibitory effects ofcostunolide were rescued by overexpression of constitutively active (CA)-NFATc1 [1]. Exposure of T24 cells to costunolide was also associated with increased expression of Bax, down-regulation of Bcl-2, survivin and significant activation of caspase-3, and it.FPTase and telomerase inhibitor (IC 50 values are 20 and 60-90 μM respectively). Apoptotic agent. Induces ROS production, activation of caspases, down-regulation of Bcl-2. Increases mitochondrial permeability transition and cytochrome C release.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been sμggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathwayA sequiterpene lactone that inhibits telomeraseCostunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathwayA sequiterpene lactone that inhibits telomerase

IUPAC Name：(3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

INCHI：InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1

InChi Key：HRYLQFBHBWLLLL-AHNJNIBGSA-N

Canonical SMILES：CC1=CCCC(=CC2C(CC1)C(=C)C(=O)O2)C

Isomeric SMILES：C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C

WGK Germany：3

RTECS：LY4270000

PubChem CID：5281437

Reaxy-Rn：14451

溶解性：Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).,

敏感性：对热敏感

比旋光度：118° (C=0.2,CHCl3)

熔点：106°C(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH317 May cause an allergic skin reaction

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P272,P333+P313,P362+P364,P264+P265,P337+P317,P332+P317,P319

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