产品名称

英文名称：Enalapril Maleate

同义词

Enalapril maleate、76095-16-4、Renitec、Glioten、Vasotec、Enalapril maleate salt、Enapren、Innovace、Naprilene、Renivace、Xanef、Baripril、Benalapril、Crinoren、Hipoartel、Amprace、Dabonal、Enacard、Reniten、Pres、Enalapril (maleate)、MK-421、Renitek、Epaned、MK-421 Maleate、enal、马来酸依那普利、依那普利马来酸盐、1-[N-[(S)-1-乙氧基羰基-3-苯丙基]-L-丙氨酰基]-L-脯氨酸马来酸盐

产品性质

CAS编号：76095-16-4

分子式：C20H28N2O5·C4H4O4

分子量：492.52

MDL号：MFCD00133304

PubChem编号：5388961

别名：马来酸依那普利|依那普利马来酸盐|1-[N-[(S)-1-乙氧基羰基-3-苯丙基]-L-丙氨酰基]-L-脯氨酸马来酸盐

英文别名：Enalapril maleate|76095-16-4|Renitec|Glioten|Vasotec|Enalapril maleate salt|Enapren|Innovace|Naprilene|Renivace|Xanef|Baripril|Benalapril|Crinoren|Hipoartel|Amprace|Dabonal|Enacard|Reniten|Pres|Enalapril (maleate)|MK-421|Renitek|Epaned|MK-421 Maleate|enal

规格或纯度：≥98%

英文名称：Enalapril Maleate

生化机理：Enalapril Maleate is an effective and potent nonsulfhydryl ACE(angiotenson-converting enzyme) inhibitor. The compound has been used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma (I50=1.2nM). ACE inhibitors disturb the enin-angiotensin- aldosterone system. Additional ACE inhibitors include Enalapril, Enalaprilat dihydrate, Enalaprilat , and Enalapril-d5 Maleate Salt, among others.Angiotensin converting enzyme inhibitor. Inhibits the conversion of angiotensin I to angiotensin II. Orally active. Antihypertensive agent. Active in vivo and in vitro .

应用：An angiotensin-converting enzyme inhibitor.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Enalapril Maleate是Enalapril的活性代谢物，与血管紧张素I竞争性结合到血管紧张素转换酶上，抑制血管紧张素I向血管紧张素II的转化。An angiotensin-converting enzyme inhibitor.Enalapril Maleate, the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II.An angiotensin-converting enzyme inhibitor.

IUPAC Name：(Z)-but-2-enedioic acid;(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid

INCHI：InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25;5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,16-,17-;/m0./s1

InChi Key：OYFJQPXVCSSHAI-QFPUQLAESA-N

Canonical SMILES：CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CCCC2C(=O)O.C(=CC(=O)O)C(=O)O

Isomeric SMILES：CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O.C(=C\C(=O)O)\C(=O)O

WGK Germany：2

RTECS：TW3666000

关联CAS：75847-73-3

PubChem CID：5388961

溶解性：Soluble in water (25 mg/ml), methanol (50 mg/ml), and ethanol (8 mg/ml).

比旋光度：[α]D -41° (C=1,MeOH)

熔点：143-145°

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowedH318 Causes serious eye damageH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P305+P351+P338,P280,P405,P501,P264,P260,P270,P330,P263,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P337+P317,P319

Merck Index：3567

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装