产品名称

英文名称：SKI II

同义词

SKI II、312636-16-1、4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol、SphK-I2、SKI-II、4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol、Sphingosine Kinase Inhibitor 2、4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol、Sphingosine Kinase Inhibitor、4-{[4-(4-chlor

产品性质

CAS编号：312636-16-1

分子式：C15H11ClN2OS

分子量：302.78

MDL号：MFCD00733553

PubChem编号：753704

英文别名：SKI II|312636-16-1|4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol|SphK-I2|SKI-II|4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol|Sphingosine Kinase Inhibitor 2|4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol|Sphingosine Kinase Inhibitor|4-{[4-(4-chlor

规格或纯度：≥98%

英文名称：SKI II

生化机理：SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 μM); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC50 = 0.9-4.6 μM).Sphingosine kinase (SK1/2) inhibitor (IC 50 values are 35 and 20 μM for SK1 and SK2 respectively). Inhibits tumor growth in vivo. Orally active.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrμg resistance.SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance.

IUPAC Name：4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol

INCHI：InChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13(19)8-6-12/h1-9,19H,(H,17,18)

InChi Key：ZFGXZJKLOFCECI-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Isomeric SMILES：C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

WGK Germany：3

PubChem CID：753704

ChEMBL Ligand：CHEMBL1076555

CAS Registry No.：312636-16-1

RCSB PDB Ligand：UUL

溶解性：DMSO 61 mg/mL Water <1 mg/mL Ethanol 61 mg/mL

密度：1.42

折光率：1.71

沸点：507.06° C at 760 mmHg

熔点：191.70°C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装