产品名称

英文名称：Wedelolactone

同义词

Wedelolactone、524-12-9、7-Methoxy-5,11,12-trihydroxycoumestan、7-Methoxy-5,11,12-trihydroxy-coumestan、IKK Inhibitor II、1,8,9-Trihydroxy-3-methoxycoumestan、CHEMBL97453、0K6L725GNS、CHEBI10037、1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one、5,11,12、7-甲氧基-5,11,12- 三羟基香豆素

产品性质

CAS编号：524-12-9

分子式：C16H10O7

分子量：314.25

MDL号：MFCD07778564

PubChem编号：5281813

别名：7-甲氧基-5,11,12- 三羟基香豆素

英文别名：Wedelolactone|524-12-9|7-Methoxy-5,11,12-trihydroxycoumestan|7-Methoxy-5,11,12-trihydroxy-coumestan|IKK Inhibitor II|1,8,9-Trihydroxy-3-methoxycoumestan|CHEMBL97453|0K6L725GNS|CHEBI10037|1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one|5,11,12

规格或纯度：≥98%(HPLC)

英文名称：Wedelolactone

生化机理：Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.Selective and irreversible IκB kinase inhibitor. Inhibits osteoclastogenesis. Suppresses LPS-induced caspase 11 expression (IC 50 =35 µM). Shows hepatoprotective effects in vivo.

应用：Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies sμggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies sμggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes.Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies suggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies suggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes.Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.

IUPAC Name：1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one

INCHI：InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChi Key：XQDCKJKKMFWXGB-UHFFFAOYSA-N

Canonical SMILES：COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

Isomeric SMILES：COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

WGK Germany：3

PubChem CID：5281813

Wikipedia：Wedelolactone

CAS Registry No.：524-12-9

ChEMBL Ligand：CHEMBL97453

ChEBI：CHEBI10037

溶解性：Soluble in DMSO (25 mg/mL), and MeOH.

敏感性：对热敏感

熔点：315 °C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH317 May cause an allergic skin reaction

预防措施声明：P261,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P330,P301+P317

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装