产品名称

英文名称：SB-203580

同义词

152121-47-6、SB 203580、SB-203580、SB203580、4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole、Adezmapimod、4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine、4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-

产品性质

CAS编号：152121-47-6

分子式：C21H16FN3OS

分子量：377.43

MDL号：MFCD00922198

PubChem编号：176155

英文别名：152121-47-6|SB 203580|SB-203580|SB203580|4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole|Adezmapimod|4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine|4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-

规格或纯度：≥98%(HPLC)

英文名称：SB-203580

生化机理：细胞可渗透的p38 MAPK抑制剂。对许多其他激酶具有选择性，但对GAK，CK1，RIP2，c-Raf和GSK3也具有抑制作用。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SB203580是一种p38 MAPK抑制剂，在THP-1细胞中IC50为0.3-0.5 μM，对SAPK3(106T)和SAPK4(106T)选择性低10倍，且阻断PKB磷酸化，IC50为3-5 μMMDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18SB203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM.MDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18

IUPAC Name：4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

INCHI：InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)

InChi Key：CDMGBJANTYXAIV-UHFFFAOYSA-N

Canonical SMILES：CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

Isomeric SMILES：CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F

WGK Germany：3

PubChem CID：176155

CAS Registry No.：152121-47-6

Wikipedia：SB_203580

DiscoveRx TREEspot：SB-203580|

ChEMBL Ligand：CHEMBL10

溶解性：Soluble in DMSO (50 mg/ml), aqueous buffers (Sparingly soluble), methanol, acetone, ethanol (~0.2 mg/ml), and 19 solution of DMFPBS(PH 7.2) (~0.5 mg/ml).

密度：1.4

敏感性：对热敏感

折光率：1.71

沸点：615.6° C

熔点：280.73°C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH318 Causes serious eye damage

预防措施声明：P305+P351+P338,P280

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装