产品名称

英文名称：Pregnenolone

同义词

pregnenolone、145-13-1、Arthenolone、3beta-Hydroxypregn-5-en-20-one、Pregnetan、Pregneton、Pregnolon、Prenolon、Regnosone、Skinostelon、Enelone、5-Pregnen-3beta-ol-20-one、Natolone、Bina-Skin、delta5-Pregnenolone、5-Pregnen-3-beta-ol-20-one、(3BETA)-3-HYDROXYPREGN-5-EN-2、孕甾烯醇酮

产品性质

CAS编号：145-13-1

分子式：C21H32O2

分子量：316.48

PubChem编号：8955

别名：孕甾烯醇酮

英文别名：pregnenolone|145-13-1|Arthenolone|3beta-Hydroxypregn-5-en-20-one|Pregnetan|Pregneton|Pregnolon|Prenolon|Regnosone|Skinostelon|Enelone|5-Pregnen-3beta-ol-20-one|Natolone|Bina-Skin|delta5-Pregnenolone|5-Pregnen-3-beta-ol-20-one|(3BETA)-3-HYDROXYPREGN-5-EN-2

规格或纯度：98%

英文名称：Pregnenolone

生化机理：One of a small number of "neurosteroids," steroids synthesized in the brain rather than peripheral sources. Decreased levels of these neurosteroids has been implicated in rodent cognitive decline with age, but studies in humans have been contradictory.Endogenous steroid prohormone and neurosteroid. PXR agonist. Anxiolytic effects and prevents diet-induced insulin resistance in vivo.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.Pregnenolone is an endogenous neurosteroid that is involved in the steroidogenesis of progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens, making it a prohormone. It has been observed to inhibit GABA-gated chloride currents by enhancing receptor desensitization. Pregnenolone is an inhibitor of GABA Receptor and an activator of PXR.An prohormone neurosteroid also a precursor to gonadal steroid hormones and the adrenal corticosteroids.

IUPAC Name：1-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

INCHI：InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1

InChi Key：ORNBQBCIOKFOEO-QGVNFLHTSA-N

Canonical SMILES：CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

Isomeric SMILES：CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C

PubChem CID：8955

Wikipedia：Pregnenolone

CAS Registry No.：145-13-1

ChEBI：CHEBI16581

DrugBank Ligand：DB02789

ChEMBL Ligand：CHEMBL253363

RCSB PDB Ligand：PLO

溶解性：Soluble in ethanol (22 mg/ml at 25 °C), chloroform, and DMSO (22 mg/ml at 25 °C). Insoluble in water, , , DMSO 22 mg/mL Water Ethanol 22 mg/mL

象形图：

信号词：Warning

危险声明：H351 Suspected of causing cancerH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P362+P364,P330,P203,P301+P317,P318,P317

产品包装