产品名称

英文名称：Glyburide

同义词

glyburide、Glibenclamide、10238-21-8、Glybenclamide、Glynase、Diabeta、Micronase、Euglucon、Daonil、Glybenzcyclamide、Semi-daonil、Apo-Glibenclamide、Azuglucon、Bastiverit、Benclamin、Betanase、Duraglucon、Euglucan、Euglykon、Glibenil、Glucolon、Orabetic、Prodiabet、Renabetic、Y、优降糖、N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N'-环己基脲、5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺

产品性质

CAS编号：10238-21-8

分子式：C23H28ClN3O5S

分子量：494

EC号：233-570-6

MDL号：MFCD00056625

PubChem编号：3488

别名：优降糖|N-对[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰基-N'-环己基脲|5-氯-N-[4-(环己基脲磺酰)苯乙基]-2-甲氧基苯甲酰胺

英文别名：glyburide|Glibenclamide|10238-21-8|Glybenclamide|Glynase|Diabeta|Micronase|Euglucon|Daonil|Glybenzcyclamide|Semi-daonil|Apo-Glibenclamide|Azuglucon|Bastiverit|Benclamin|Betanase|Duraglucon|Euglucan|Euglykon|Glibenil|Glucolon|Orabetic|Prodiabet|Renabetic|Y

规格或纯度：≥99%

英文名称：Glyburide

生化机理：Glibenclamide is a sulfonylurea compound that modulates insulin production. Sulfonylureas bind to ATP-dependent K+ channels in beta cells of the pancreas, depolarizing them and stimulating the release of Ca2+, which in turn stimulates insulin production. Glibenclamide, a sulphonylurea oral hypoglycaemic agent is a widely used antagonist of cromakalim-activated K+ channels in smooth muscle. Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. Glibenclamide is widely used for treatment of type 2-diabetes and it has been signaled as antiproliferative in several tumor cell lines.Selective blocker of ATP-sensitive (KIR6.x) inward rectifier K + channels.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Glibenclamide (格列本脲; Glyburide) 是磺酰脲类化合物，能调节胰岛素的产生。An ATP-dependent KIR6 and CFTR Cl- channel blockerGlibenclamide(Glyburide) is a sulfonylurea compound that modulates insulin production.An ATP-dependent KIR6 and CFTR Cl- channel blocker

ALogP：4.8

IUPAC Name：5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide

INCHI：InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChi Key：ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

Isomeric SMILES：COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3

WGK Germany：2

RTECS：YS4725200

PubChem CID：3488

Reaxy-Rn：2230085

DrugBank Ligand：DB01016

CAS Registry No.：10238-21-8

ChEBI：CHEBI5441

Wikipedia：Glibenclamide

ChEMBL Ligand：CHEMBL472

BindingDB Ligand：50012957

RCSB PDB Ligand：GBM

PEP：glibenclamide

DrugCentral Ligand：1314

溶解性：Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (136), methanol (1250), and DMF. Insoluble in water.

密度：1.4

敏感性：对热敏感

折光率：1.62

熔点：171-174°C

象形图：

信号词：Warning

危险声明：H413 May cause long lasting harmful effects to aquatic lifeH302 Harmful if swallowed

预防措施声明：P273,P501,P264,P270,P330,P301+P317

Merck Index：4478

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装