产品名称

英文名称：Apoptosis Activator 2

同义词

Apoptosis Activator 2、79183-19-0、1-(3,4-dichlorobenzyl)indoline-2,3-dione、1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione、MDK83190、1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione、RSY8DE8DGH、C15H9Cl2NO2、1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione、Apoptosi

产品性质

CAS编号：79183-19-0

分子式：C15H9Cl2NO2

分子量：306.14

PubChem编号：1901244

英文别名：Apoptosis Activator 2|79183-19-0|1-(3,4-dichlorobenzyl)indoline-2,3-dione|1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione|MDK83190|1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione|RSY8DE8DGH|C15H9Cl2NO2|1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione|Apoptosi

规格或纯度：≥98%

英文名称：Apoptosis Activator 2

生化机理：Apoptosis Activator 2 is a cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 μM for Jurkat, Molt-4, and CCRF-CEM). Apoptosis Activator 2 shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Apoptosis Activator 2 is an activator of caspase-3.Cell-permeable cytochrome c caspase activator. Promoting cytochrome-c dependent oligomerization of Apaf-1 into the mature apoptosome. Induces apoptosis in tumor cells (IC 50 = ~4 µM).

应用：An indoledione caspase activator

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Apoptosis Activator 2强诱导caspase-3激活， PARP分裂， DNA断裂，导致细胞破坏(Apaf-1依赖性的)，IC50约为4 μM，抑制HMEC， PREC和MCF-10A细胞活性。An indoledione caspase activatorApoptosis Activator 2 strongly induces caspase-3 activation, PARP cleavage, and DNA fragmentation which leads to the destruction of cells (Apaf-1 dependent) with IC50 of ~4 μM, inactive to HMEC, PREC, or MCF-10A cells.An indoledione caspase activator

IUPAC Name：1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione

INCHI：InChI=1S/C15H9Cl2NO2/c16-11-6-5-9(7-12(11)17)8-18-13-4-2-1-3-10(13)14(19)15(18)20/h1-7H,8H2

InChi Key：KGRJPLRFGLMQMV-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

Isomeric SMILES：C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

PubChem CID：1901244

溶解性：Soluble in DMSO (5 mg/ml), methanol (5 mg/ml), and ethanol.; DMSO 61 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对光敏感

产品包装