产品名称

英文名称：GW441756

同义词

504433-23-2、GW 441756、1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one、GW441756、GW-441756、GW441756 hydrochloride、504433-24-3、(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one、CHEMBL176544、3-((1-Me

产品性质

CAS编号：504433-23-2

分子式：C17H13N3O

分子量：275.3

PubChem编号：9943465

英文别名：504433-23-2|GW 441756|1,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2H-pyrrolo[3,2-b]pyridin-2-one|GW441756|GW-441756|GW441756 hydrochloride|504433-24-3|(Z)-3-((1-methyl-1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one|CHEMBL176544|3-((1-Me

规格或纯度：98%

英文名称：GW441756

生化机理：DescriptionIC50 Value 2nM [1]GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.in vitro GW441756 specifically blocked TrkA-induced cell death in a dose-dependent manner, but there was no effect in uninduced cells. TrkA ability to induce γH2AX production was significantly downregulated by both K-252a and GW441756 in the absence of DNA damage inducer. In addition, it was also suppressed by K-252a during DNA damage by doxorubicin treatment, but not by GW441756 [2].in vivo N/AClinical trial N/A.Potent, selective TrKA tyrosine kinase inhibitor (IC 50 = 2 nM). Displays >100-fold selectivity over a range of other kinases. Antineoplastic effects.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：GW441756 是一种有效的，选择性的TrkA抑制剂，IC50为2 nM，对c-Raf1和CDK2几乎没有抑制活性。GW441756 可增加caspase-3并诱导凋亡。

IUPAC Name：(3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-pyrrolo[3,2-b]pyridin-2-one

INCHI：InChI=1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-13-16-14(19-17(13)21)6-4-8-18-16/h2-10H,1H3,(H,19,21)/b13-9-

InChi Key：NXNQLECPAXXYTR-LCYFTJDESA-N

Canonical SMILES：CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC=N4)NC3=O

Isomeric SMILES：CN1C=C(C2=CC=CC=C21)/C=C\3/C4=C(C=CC=N4)NC3=O

PubChem CID：9943465

溶解性：DMSO 25 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装