产品名称

英文名称：Batimastat

同义词

batimastat、130370-60-4、BB-94、Batimastat (BB-94)、BB94、BB 94、Batimastat (MMP Inhibitor)、Batimastat(BB-94)、Butanediamide, N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-、CHEMBL279786、(2

产品性质

CAS编号：130370-60-4

分子式：C23H31N3O4S2

分子量：477.64

MDL号：MFCD00866533

PubChem编号：5362422

英文别名：batimastat|130370-60-4|BB-94|Batimastat (BB-94)|BB94|BB 94|Batimastat (MMP Inhibitor)|Batimastat(BB-94)|Butanediamide, N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-, (2R,3S)-|CHEMBL279786|(2

规格或纯度：≥98%

英文名称：Batimastat

生化机理：Batimastat is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor. Batimastat is hydroxamate-type inhibitor of matrix metalloproteinases (MMP).It inhibits the growth and spread of lung tumors,breast cancer regrowth and human colon tumor growth and spread in mouse models. Batimastat reduces MMP-mediated vascular dysfunction and vessel wall damage and enhances the sealing ability and bond strength of dental adhesives.Potent, broad-spectrum MMP inhibitor (IC 50 values are 3 (MMP-1), 4 (MMP-2), 4 (MMP-9), 6 (MMP-7), 20 nM (MMP-3)). Anticancer activity in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Batimastat 是一种有效的广谱 MMP 抑制剂，作用于 MMP-1，MMP-2，MMP-9，MMP-7 和 MMP-3，IC50 分别为 3，4，4，6 和 20 nM。Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133.Batimastat is a potent broad spectrum MMP inhibitor with IC50 of 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3, respectively.Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133.

PubChem SID：488195427

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195427

IUPAC Name：(2S,3R)-N-hydroxy-N'-[(2S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]-3-(2-methylpropyl)-2-(thiophen-2-ylsulfanylmethyl)butanediamide

INCHI：InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1

InChi Key：XFILPEOLDIKJHX-QYZOEREBSA-N

Canonical SMILES：CC(C)CC(C(CSC1=CC=CS1)C(=O)NO)C(=O)NC(CC2=CC=CC=C2)C(=O)NC

Isomeric SMILES：CC(C)C[C@H]([C@H](CSC1=CC=CS1)C(=O)NO)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NC

WGK Germany：3

PubChem CID：5362422

CAS Registry No.：130370-60-4

DrugBank Ligand：DB03880

Wikipedia：Batimastat

ChEMBL Ligand：CHEMBL279786

RCSB PDB Ligand：BAT

溶解性：DMSO 96 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

产品包装