产品名称

英文名称：Flavopiridol HCl

同义词

Flavopiridol hydrochloride、131740-09-5、Alvocidib hydrochloride、Flavopiridol HCl、HL 275、Flavopiridol (Hydrochloride)、HMR 1275、MDL 107826A、NSC 649890、Alvocidib hydrochloride [USAN]、HL-275、L 86 8275、D48MS3A6N9、HMR-1275、2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S、夫拉平度盐酸盐

产品性质

CAS编号：131740-09-5

分子式：C21H20ClNO5.HCl

分子量：438.3

PubChem编号：9910986

别名：夫拉平度盐酸盐

英文别名：Flavopiridol hydrochloride|131740-09-5|Alvocidib hydrochloride|Flavopiridol HCl|HL 275|Flavopiridol (Hydrochloride)|HMR 1275|MDL 107826A|NSC 649890|Alvocidib hydrochloride [USAN]|HL-275|L 86 8275|D48MS3A6N9|HMR-1275|2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S

规格或纯度：≥99%

英文名称：Flavopiridol HCl

生化机理：Flavopiridol hydrochloride is a pan-cdk inhibitor.Potent ATP-competitive CDK and CDC25 phosphatase inhibitor (IC 50 values are 40, 40, 40, 40 and 300 nM for CDK1,2,4,6 and 7 respectively). Inhibits EGFR and PKA (IC 50 values are 21 and 122 μM respectively). Induces cell cycle arrest at G 1 and G 2 phase.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Product DescribtionAlvocidib Hydrochloride is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.

IUPAC Name：2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one;hydrochloride

INCHI：InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1

InChi Key：LGMSNQNWOCSPIK-LWHGMNCYSA-N

Canonical SMILES：CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

Isomeric SMILES：CN1CC[C@@H]([C@@H](C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O.Cl

PubChem CID：9910986

溶解性：DMSO 88 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对湿度敏感

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

产品包装