产品名称

英文名称：Darapladib

同义词

Darapladib、356057-34-6、SB-480848、Darapladib (SB-480848)、SB 480848、N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide、UI1U1MYH09、CHEM

产品性质

CAS编号：356057-34-6

分子式：C36H38F4N4O2S

分子量：666.77

PubChem编号：9939609

英文别名：Darapladib|356057-34-6|SB-480848|Darapladib (SB-480848)|SB 480848|N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide|UI1U1MYH09|CHEM

规格或纯度：≥98%

英文名称：Darapladib

生化机理：有力的脂蛋白相关磷脂酶A2（lp-PLA2）抑制剂（整个人血浆中IC50 = 5 nM）。

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Darapladib (SB-480848)是不可逆的lipoprotein-associated phospholipase A2 (Lp-PLA2)抑制剂，其IC50为0.25 nM。Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM.

ALogP：7

IUPAC Name：N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide

INCHI：InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3

InChi Key：WDPFJWLDPVQCAJ-UHFFFAOYSA-N

Canonical SMILES：CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(C=C5)F

Isomeric SMILES：CCN(CC)CCN(CC1=CC=C(C=C1)C2=CC=C(C=C2)C(F)(F)F)C(=O)CN3C4=C(CCC4)C(=O)N=C3SCC5=CC=C(C=C5)F

PubChem CID：9939609

CAS Registry No.：356057-34-6

ChEMBL Ligand：CHEMBL204021

Wikipedia：Darapladib

RCSB PDB Ligand：5HV

溶解性：溶于DMSO, 最高浓度 (mg/mL) 66.68, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 66.68, 最高浓度(mM) 100

象形图：

信号词：Danger

危险声明：H318 Causes serious eye damageH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P273,P280,P501,P391,P264+P265,P305+P354+P338,P317

产品包装