产品名称

英文名称：Azilsartan

同义词

1794817-45-0、Azilsartan [USAN]、AZILSARTAN [INN]、CCG-269296、D08864、CS-1396、2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid、2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl4-yl]met、阿齐沙坦

产品性质

CAS编号：147403-03-0

分子式：C25H20N4O5

分子量：456.45

MDL号：MFCD00916395

PubChem编号：135415867

别名：阿齐沙坦

英文别名：1794817-45-0|Azilsartan [USAN]|AZILSARTAN [INN]|CCG-269296|D08864|CS-1396|2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid|2-Ethoxy-1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl4-yl]met

规格或纯度：≥99%

英文名称：Azilsartan

生化机理：Azilsartan is a highly potent and slowly dissociating Angiotensin II type 1 (AT1) receptor blocker (ARB) with an IC50 of 2.6 nM. It is the active form of Azilsartan medoxomil, used for treatment of hypertension. Azilsartan may also have potentially beneficial effects on metabolic syndrome including insulin sensitizing activity that may involve more than just blockade of AT(1) receptors.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：10mg、50mg卖完停产，不再备货

ALogP：4.4

IUPAC Name：2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid

INCHI：InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32)

InChi Key：KGSXMPPBFPAXLY-UHFFFAOYSA-N

Canonical SMILES：CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O

Isomeric SMILES：CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O

WGK Germany：3

PubChem CID：135415867

Wikipedia：Azilsartan

CAS Registry No.：147403-03-0

ChEMBL Ligand：CHEMBL57242

PEP：azilsartan

GPCRdb Ligand：azilsartan

溶解性：DMSO soluble15 mg/mL

敏感性：对热敏感

熔点：188 °C(dec.)

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P280,P405,P501,P264,P260,P270,P263,P203,P318,P319

产品包装