产品名称

英文名称：Oseltamivir phosphate

同义词

Oseltamivir phosphate、204255-11-8、Tamiflu、Oseltamivir (phosphate)、Oseltamir Phosphate、Ro 64-0796/002、Oseltamivir (as phosphate)、4A3O49NGEZ、Agucort、Aseltamivir phosphate、CHEBI7799、GS 4104、ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-e、磷酸奥司他韦、达菲、(3R,4R,5S)-4-乙酰氨-5-氨基-3-(1-乙基丙氧基)-1-环己烯-1-羧酸乙酯 磷酸盐

产品性质

CAS编号：204255-11-8

分子式：C16H28N2O4·H3PO4

分子量：410.4

MDL号：MFCD08059548

PubChem编号：78000

别名：磷酸奥司他韦|达菲|(3R,4R,5S)-4-乙酰氨-5-氨基-3-(1-乙基丙氧基)-1-环己烯-1-羧酸乙酯 磷酸盐

英文别名：Oseltamivir phosphate|204255-11-8|Tamiflu|Oseltamivir (phosphate)|Oseltamir Phosphate|Ro 64-0796/002|Oseltamivir (as phosphate)|4A3O49NGEZ|Agucort|Aseltamivir phosphate|CHEBI7799|GS 4104|ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-e

规格或纯度：≥99%

英文名称：Oseltamivir phosphate

生化机理：病毒神经氨酸酶抑制剂前药；代谢为GS4071。代谢物对多种流感病毒株的神经氨酸酶均具有有效的抑制作用（IC50值范围为0.3至2 nM）。在体外抑制流感病毒感染的细胞作用（IC50值范围从0.6到150 nM）。对H1N1和H3N2甲型流感病毒株显示出最高的效力。抑制小鼠中的H1N1流感感染。

应用：An antiviral agent

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：Oseltamivir phosphate 是一种竞争性神经氨酸酶抑制剂。 Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrμg oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its active metabolite, the free carboxylate of oseltamivir (GS4071). Oseltamivir phosphate (Tamiflu) serves as a competitive inhibitor towards sialic acid, found on the surface proteins of normal host cells. By blocking the activity of the viral neuraminidase enzyme, oseltamivir phosphate (Tamiflu) prevents new viral particles from being released by infected cells. Oseltamivir phosphate (Tamiflu) is an antiviral drμg that slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.An antiviral agentOseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its active metabolite, the free carboxylate of oseltamivir (GS4071). Oseltamivir phosphate (Tamiflu) serves as a competitive inhibitor towards sialic acid, found on the surface proteins of normal host cells. By blocking the activity of the viral neuraminidase enzyme, oseltamivir phosphate (Tamiflu) prevents new viral particles from being released by infected cells. Oseltamivir phosphate (Tamiflu) is an antiviral drug that slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell.An antiviral agent

PubChem SID：488185493

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488185493

IUPAC Name：ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate;phosphoric acid

INCHI：InChI=1S/C16H28N2O4.H3O4P/c1-5-12(6-2)22-14-9-11(16(20)21-7-3)8-13(17)15(14)18-10(4)19;1-5(2,3)4/h9,12-15H,5-8,17H2,1-4H3,(H,18,19);(H3,1,2,3,4)/t13-,14+,15+;/m0./s1

InChi Key：PGZUMBJQJWIWGJ-ONAKXNSWSA-N

Canonical SMILES：CCC(CC)OC1C=C(CC(C1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O

Isomeric SMILES：CCC(CC)O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)OCC.OP(=O)(O)O

PubChem CID：78000

溶解性：溶于DMSO, 最高浓度 (mg/mL) 41.04, 最高浓度(mM) 100；溶于water, 最高浓度 (mg/mL) 41.04, 最高浓度(mM) 100

敏感性：易吸湿

沸点：473.3°C at 760 mmHg

熔点：197 - 204 °C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowedH317 May cause an allergic skin reactionH312 Harmful in contact with skinH332 Harmful if inhaledH302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P271,P270,P304+P340,P272,P333+P313,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317

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