产品名称

英文名称：N-Acetyl-L-Cysteine

同义词

Fluprowit 、 Airbron 、 Fluimucil 、 Flumucetin 、 mercapturic acid 、 NAC 、 LNAC 、 Fabrol 、 Acetein 、 Mucomyst 、 Parvolex 、 Ac-Cys-OH 、 acetylcysteine 、 Fluimucetin 、 Mucosil 、 Respaire 、 Acetadote 、 L-Acetylcysteine 、 N-Acetylcysteine 、 N-Acetyl-cysteine 、 B、乙酰半胱氨酸 、 N-乙酰基-L-半胱氨酸

产品性质

CAS编号：616-91-1

分子式：C5H9NO3S

分子量：163.19

Beilstein号：1724426

EC号：210-498-3

MDL号：MFCD00004880

PubChem编号：12035

别名：乙酰半胱氨酸 | N-乙酰基-L-半胱氨酸

英文别名：Fluprowit | Airbron | Fluimucil | Flumucetin | mercapturic acid | NAC | LNAC | Fabrol | Acetein | Mucomyst | Parvolex | Ac-Cys-OH | acetylcysteine | Fluimucetin | Mucosil | Respaire | Acetadote | L-Acetylcysteine | N-Acetylcysteine | N-Acetyl-cysteine | B

规格或纯度：99%

英文名称：N-Acetyl-L-Cysteine

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：N-Acetyl-L-cysteine is an acetylated amino acid with antioxidant and mucolytic properties. These two activities have made N-Acetyl-L-cysteine particularly relevant in cystic fibrosis studies, where the antioxidant/reducing character of the compound is described to ameliorate the characteristic systemic redox imbalance state of cystic fibrosis and the mucolytic properties of the compound are shown to impede upon the congestion and inflammation correlated to this redox state. As a mucolytic, N-Acetyl-L-cysteine serves to dissipate disulfide bonds across mucoproteins, loosening and clearing the viscosity of sputum. N-Acetyl-L-cysteine shows complimentary action to glutathione, both demonstrating antioxidant activity throμgh their thiol functionality, and both are shown to protect against peroxidative stress related to septic shock. N-Acetyl-L-cysteine has also been shown to induce apoptosis in vascular smooth muscle cells, indicating that these cells respond differently to changes in reduction-oxidation state than other tissues that are normally protected by the presence of antioxidants. This observation in vascular smooth muscle cells indicates N-Acetyl-L-cysteine as an interventional tool upon arteriosclerotic proliferation of these cells.An antioxidant mucolytic acetylated amino acid.

ALogP：0.4

PubChem SID：488181517

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488181517

IUPAC Name：(2R)-2-acetamido-3-sulfanylpropanoic acid

INCHI：InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChi Key：PWKSKIMOESPYIA-BYPYZUCNSA-N

Canonical SMILES：CC(=O)NC(CS)C(=O)O

Isomeric SMILES：CC(=O)N[C@@H](CS)C(=O)O

WGK Germany：2

RTECS：HA1660000

PubChem CID：12035

CAS Registry No.：616-91-1

ChEMBL Ligand：CHEMBL600

BindingDB Ligand：50420190

DrugBank Ligand：DB06151

RCSB PDB Ligand：1ZT, SC2

DrugCentral Ligand：66

溶解性：Soluble in water (100 mg/ml) with heating and obtained a clear, colorless solution, 1 in 2 of ethanol, DMSO (≥33 mg/ml) at 25 °C, hot isopropyl alcohol, methyl acetate, ethyl acetate and methanol. Practically insoluble in chloroform, and ether.

敏感性：对空气敏感

比旋光度：24 ° (JPC Method)

熔点：109-111°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：88

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装