产品名称

英文名称：Aliskiren Hemifumarate

同义词

Aliskiren hemifumarate、173334-58-2、Tekturna、Aliskiren fumarate、Aliskiren (hemifumarate)、Enviage、Riprazo、SPP-100B、Sprimeo、UNII-C8A0P8G029、CHEBI53777、C8A0P8G029、NSC-759185、ALISKIREN (AS FUMARATE)、NSC 759185、CGP 60536、TEKAMLO COMPONENT ALISKIREN HEMIFUMARAT、阿利克仑半富马酸盐

产品性质

CAS编号：173334-58-2

分子式：C30H53N3O6·1/2C4H4O4

分子量：609.83

PubChem编号：6918427

别名：阿利克仑半富马酸盐

英文别名：Aliskiren hemifumarate|173334-58-2|Tekturna|Aliskiren fumarate|Aliskiren (hemifumarate)|Enviage|Riprazo|SPP-100B|Sprimeo|UNII-C8A0P8G029|CHEBI53777|C8A0P8G029|NSC-759185|ALISKIREN (AS FUMARATE)|NSC 759185|CGP 60536|TEKAMLO COMPONENT ALISKIREN HEMIFUMARAT

规格或纯度：≥98%

英文名称：Aliskiren Hemifumarate

生化机理：强大的肾素抑制剂（人和大鼠的IC50分别为0.6和80 nM）。在一系列其他天冬氨酸蛋白酶（> 5000 nM）上表现出对肾素的选择性。降低高血压啮齿动物模型的血压。口服有效。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Aliskiren Hemifumarate是一种直接肾素抑制剂，IC50为1.5 nM。Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

PubChem SID：488195878

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195878

IUPAC Name：(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioic acid

INCHI：InChI=1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1

InChi Key：KLRSDBSKUSSCGU-KRQUFFFQSA-N

Canonical SMILES：CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O

Isomeric SMILES：CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=C/C(=O)O)\C(=O)O

PubChem CID：6918427

溶解性：溶于water, 最高浓度 (mg/mL) 60.98, 最高浓度(mM) 100；溶于DMSO, 最高浓度 (mg/mL) 60.98, 最高浓度(mM) 100

敏感性：对热、光线敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

产品包装