产品名称

英文名称：Edoxaban

同义词

NDU3J18APO 、 N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 、 DU-176 、 UNII-NDU3J18APO 、 DU-176b、伊多塞班

产品性质

CAS编号：480449-70-5

分子式：C24H30ClN7O4S

分子量：548.06

PubChem编号：10280735

别名：伊多塞班

英文别名：NDU3J18APO | N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide | DU-176 | UNII-NDU3J18APO | DU-176b

规格或纯度：≥98%

英文名称：Edoxaban

生化机理：Description IC50 ValueN/A Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention in patients with atrial fibrillation, an elderly population that frequently receives aspirin (ASA) and/or nonsteroidal anti-inflammatory drμgs for concurrent illnesses[1]. in vitro Edoxaban PK was not affected by concomitant low-dose ASA or naproxen, but high-dose ASA increased systemic exposure of edoxaban by approximately 30%. The effects of edoxaban on prothrombin time, activated partial thromboplastin time, international normalized ratio, anti-FXa, and intrinsic FXa activity were not influenced by administration with ASA or naproxen. Inhibition of platelet aggregation by high-dose ASA, low-dose ASA, or naproxen was not affected by edoxaban[1]. in vivo Forty-eight subjects, aged 18 to 45 years, received either edoxaban 60 mg once daily × 7 days (n = 24) or digoxin 0.25 mg twice daily × 2 days and once daily × 5 days (n = 24) and

储存温度：2-8°C储存

运输条件：冰袋运输

备注：50mg、10mg卖完停产，不再备货

产品介绍：Edoxaban(DU-176)是口服的FXa抑制剂，临床开发用于中风预防。Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.

IUPAC Name：N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide

INCHI：InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1

InChi Key：HGVDHZBSSITLCT-JLJPHGGASA-N

Canonical SMILES：CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C

Isomeric SMILES：CN1CCC2=C(C1)SC(=N2)C(=O)N[C@@H]3C[C@H](CC[C@@H]3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C

PubChem CID：10280735

CAS Registry No.：480449-70-5

Wikipedia：Edoxaban

ChEMBL Ligand：CHEMBL1269025

PEP：edoxaban

Reactome Reaction：R-HSA-9015122, R-HSA-9015111

Reactome Drug：R-ALL-9038742

DrugCentral Ligand：4897

溶解性：25°C DMSO

象形图：

信号词：Warning

危险声明：H373 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P501,P260,P319

产品包装