产品名称

英文名称：N-stearoyl-D-erythro-sphingosine

同义词

N-Stearoylsphingosine、C18 Ceramide、2304-81-6、N-Stearoyl-D-sphingosine、N-stearoyl-D-erythro-sphingosine、Cer(d181/180)、C18 Cer、Ceramide (d181/180)、N-(octadecanoyl)-sphing-4-enine、N-(stearoyl)-ceramide、N-octadecanoylsphingosine、N-(octadecanoyl)-ceramide、N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-十八烷酰胺、C18 Ceramide (d181/180)

产品性质

CAS编号：2304-81-6

分子式：C36H71NO3

分子量：565.954

Beilstein号：1717539

MDL号：MFCD02259139

PubChem编号：5283565

别名：N-[(1S,2R,3E)-2-羟基-1-(羟基甲基)-3-十七碳烯-1-基]-十八烷酰胺|C18 Ceramide (d181/180)

英文别名：N-Stearoylsphingosine|C18 Ceramide|2304-81-6|N-Stearoyl-D-sphingosine|N-stearoyl-D-erythro-sphingosine|Cer(d181/180)|C18 Cer|Ceramide (d181/180)|N-(octadecanoyl)-sphing-4-enine|N-(stearoyl)-ceramide|N-octadecanoylsphingosine|N-(octadecanoyl)-ceramide|

规格或纯度：>99%

英文名称：N-stearoyl-D-erythro-sphingosine

生化机理：在神经退行性病变中，基于 C18 神经酰胺的衍生物的量较少。它有利于胶质瘤细胞中基于内质网的应力和自噬。少量的C18-神经酰胺，也可影响人头颈部鳞状细胞癌。C18 神经酰胺可抑制肿瘤进展

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：1mg卖完停产，不再备货

产品介绍：C18 神经酰胺 (d181/180) 合成由神经酰胺合成酶 (CER) 1 和 5 催化。它是细胞膜的组成部分，而与不饱和神经酰胺相比，它的凝胶形成能力低C18 神经酰胺（d181/180）已用于诱导 Manduca 胚胎细胞系（MRRL-CH1）中细胞凋亡 。其用作采用液相色谱-质谱法检测肝组织中神经酰胺的量的标准品，目的是抑制发生β-葡糖脑苷脂酶（GCase）突变的人胚肾细胞（HEK29）中的神经酰胺酶。C18 Ceramide (d181/180) synthesis is catalyzed by ceramide synthase (CERS) 1 and 5. It is a component of cellular membrane and has low gel forming ability compared to unsaturated ceramideC18 Ceramide (d181/180) has been used· to induce apoptosis in Manduca embryonic cell line (MRRL-CH1)· as a standard to quantify ceramide from liver tissue using liquid chromatography-mass spectrometry· to inhibit ceramidase in human embryonic kidney cells (HEK29) with β-glucocerebrosidase (GCase) mutation

IUPAC Name：N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamide

INCHI：InChI=1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1

InChi Key：VODZWWMEJITOND-NXCSZAMKSA-N

Canonical SMILES：CCCCCCCCCCCCCCCCCC(=O)NC(CO)C(C=CCCCCCCCCCCCCC)O

Isomeric SMILES：CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H](/C=C/CCCCCCCCCCCCC)O

PubChem CID：5283565

溶解性：Soluble in chloroform. Insoluble in water.

产品包装