产品名称

英文名称：HA14-1

同义词

ha14-1、65673-63-4、Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate、HA 14-1、HA-14-1、927635-64-1、Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate、(alphaR,4R)-rel-2-amino-6-bromo-alpha-cyano-3

产品性质

CAS编号：65673-63-4

分子式：C17H17BrN2O5

分子量：409.23

PubChem编号：3549

英文别名：ha14-1|65673-63-4|Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate|HA 14-1|HA-14-1|927635-64-1|Ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-1-benzopyran-3-carboxylate|(alphaR,4R)-rel-2-amino-6-bromo-alpha-cyano-3

规格或纯度：≥98%

英文名称：HA14-1

生化机理：HA14-1 is a small molecule and nonpeptidic ligand of a Bcl-2 surface pocket with IC50 of approximately 9 μM. HA14-1 induces the apoptosis of HL-60 cells in a dose-dependent manner via caspase activation. HA14-1 shows cytotoxic effects on HF1A3, HF4.9 and HF28RA follicular lymphoma B cell lines with LC50 of 4.5 μM, 12.6 μM and 8.1 μM respectively. HA14-1 induces apoptosis of HF1A3, HF4.9 and HF28RA cells via caspase and ROS.Cell permeable Bcl-2 inhibitor. BH-3 mimetic. Disrupts Bax and Bcl-2 interactions. Apoptotic anticancer agent.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：不稳定重新制作解决方案并立即使用。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：HA14-1是非肽类Bcl-2表面口袋配体，IC50为9 μM。A cell-permeable, nonpeptidic Bcl-2 inhibitorHA14-1 is a non-peptidic ligand of a Bcl-2 surface pocket with IC50 of ~9 μM.A cell-permeable, nonpeptidic Bcl-2 inhibitor

IUPAC Name：ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

INCHI：InChI=1S/C17H17BrN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3

InChi Key：SXJDCULZDFWMJC-UHFFFAOYSA-N

Canonical SMILES：CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N

Isomeric SMILES：CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N

WGK Germany：3

PubChem CID：3549

溶解性：DMSO

密度：1.48

折光率：1.57

沸点：535.1° C at 760 mmHg

熔点：105-108°C

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装