产品名称

英文名称：Azathioprine

同义词

azathioprine、446-86-6、Imuran、Azothioprine、Azathioprin、Azamun、Azanin、Azatioprin、Azasan、Ccucol、Imurek、Imurel、Muran、Azathiopurine、Rorasul、Azathioprinum、BW 57-322、NSC-39084、BW-57-322、Azatioprina、6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine、NCI-C03474、NSC 39084、依木兰、硫唑嘌呤

产品性质

CAS编号：446-86-6

分子式：C9H7N7O2S

分子量：277.26

EC号：207-175-4

MDL号：MFCD00069203

PubChem编号：2265

别名：依木兰|硫唑嘌呤

英文别名：azathioprine|446-86-6|Imuran|Azothioprine|Azathioprin|Azamun|Azanin|Azatioprin|Azasan|Ccucol|Imurek|Imurel|Muran|Azathiopurine|Rorasul|Azathioprinum|BW 57-322|NSC-39084|BW-57-322|Azatioprina|6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine|NCI-C03474|NSC 39084

规格或纯度：≥98%

英文名称：Azathioprine

生化机理：Azathioprine is an immunosuppressive purine antimetabolite. The mechanism of action of azathioprine is as a Nucleic Acid Synthesis Inhibitor;Has shown promise in treatment of alopecia areata (autoimmune hair loss), with no difference in effectiveness between genders.Antimetabolite and potent immunosuppressive agent. Purine analog. 6-mercaptopurine prodrug. Inhibits DNA synthesis. Inhibits Rac1 and c-Jun-terminal-N-kinase activation. Shows antiproliferative effects in vivo. Orally active.

应用：An immunosuppressive antimetabolite that interferes with the synthesis of purines.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Azathioprine 是一种免疫抑制剂。An immunosuppressive antimetabolite that interferes with the synthesis of purines.Azathioprine is a drug that suppresses the immune system and is used in organ transplantation and autoimmune diseaseAn immunosuppressive antimetabolite that interferes with the synthesis of purines.

ALogP：0.1

PubChem SID：488179682

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488179682

IUPAC Name：6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine

INCHI：InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChi Key：LMEKQMALGUDUQG-UHFFFAOYSA-N

Canonical SMILES：CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]

Isomeric SMILES：CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]

WGK Germany：3

RTECS：UO8925000

PubChem CID：2265

Reaxy-Rn：1225351

DrugBank Ligand：DB00993

CAS Registry No.：446-86-6

ChEMBL Ligand：CHEMBL1542

Wikipedia：Azathioprine

BitterDB Ligand：56

PEP：azathioprine

Immunopaedia Search：azathioprine

DrugCentral Ligand：269

溶解性：Soluble in Dichloromethane and DMSO

敏感性：对热和光线敏感

熔点：244°C(dec.)(lit.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH360 May damage fertility or the unborn childH340 May cause genetic defectsH350 May cause cancer

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

Merck Index：902

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装