产品名称

英文名称：Clomipramine HCl

同义词

Clomipramine hydrochloride、17321-77-6、Clomipramine HCL、Anafranil、3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride、Anaphranil、Chlorimipramine hydrochloride、3-Chloroimipramine hydrochloride、Chloroimipramine mono、盐酸氯米帕明

产品性质

CAS编号：17321-77-6

分子式：C19H23ClN2·HCl

分子量：351.31

EC号：241-344-3

MDL号：MFCD00069234

PubChem编号：68539

别名：盐酸氯米帕明

英文别名：Clomipramine hydrochloride|17321-77-6|Clomipramine HCL|Anafranil|3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine hydrochloride|Anaphranil|Chlorimipramine hydrochloride|3-Chloroimipramine hydrochloride|Chloroimipramine mono

规格或纯度：≥99%

英文名称：Clomipramine HCl

生化机理：Clomipramine hydrochloride (Anafranil) is a hydrochloride salt of clomipramine which is an ST (serotonin transporter/SERT), SLC6A2 (norepinephrine transporter/NET), and DAT (dopamine transporter) blocker with Ki of 0.14, 54 and 3 nM, respectively. Clomipramine hydrochloride is a tricyclic antidepressant, a norepinephrine-reuptake inhibitor, and an antiobsessional drμg. Clomipramine hydrochloride is an inhibitor of D2 receptor (Ki = 162 nM), D3 receptor (Ki = 30 nM), AR (α1-adrenergic receptor, Ki = 3.2 nM), α2-adrenergic receptor (Ki = 525 nM), H1 receptor (Ki = 31 nM), mACh receptors (Ki = 37 nM), 5-HT2A receptor (Ki = 36 nM), 5-HT2C receptor (Ki = 65 nM), 5-HT3 receptor (Ki = 85 nM), 5-HT6 receptor (Ki = 54 nM), 5-HT7 receptor (Ki = 127 nM), D1 receptor (Ki = 219 nM).Tricyclic antidepressant agent. Selective α1-adrenoceptor antagoinst (K i values are 3 and 525 nM for α1 and α2 respectively. SERT, NET and DAT blocker (K i values are 0.14, 54 and 3 nM respectively).

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Clomipramine HCl 是Clomipramine的盐酸盐，抑制5-羟色胺转运蛋白（SERT），去甲肾上腺素转运体（NET）和多巴胺转运蛋白（DAT），Ki分别为0.14， 54和3 nM。A selective ST, SLC6A2, and DAT inhibitorClomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively.A selective ST, SLC6A2, and DAT inhibitor

PubChem SID：488184172

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488184172

IUPAC Name：3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine;hydrochloride

INCHI：InChI=1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChi Key：WIMWMKZEIBHDTH-UHFFFAOYSA-N

Canonical SMILES：CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl

Isomeric SMILES：CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl

WGK Germany：3

RTECS：HN9055000

PubChem CID：68539

溶解性：Soluble in water (125 mg/ml), ethanol (70 mg/ml at 25 °C), chloroform (13), DMSO (70 mg/ml at 25 °C), and dilute aqueous acid.

敏感性：对热和光敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH312 Harmful in contact with skinH400 Very toxic to aquatic lifeH332 Harmful if inhaledH410 Very toxic to aquatic life with long lasting effectsH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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