产品名称

英文名称：Noopept

同义词

Noopept、157115-85-0、Omberacetam、GVS-111、(S)-Ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate、n-phenylacetyl-l-prolylglycine ethyl ester、Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester、ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]am、N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

产品性质

CAS编号：157115-85-0

分子式：C17H22N2O4

分子量：318.37

MDL号：MFCD00941121

PubChem编号：180496

别名：N-(1-(苯基乙酰基)-L-脯氨酰)甘氨酸乙酯

英文别名：Noopept|157115-85-0|Omberacetam|GVS-111|(S)-Ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate|n-phenylacetyl-l-prolylglycine ethyl ester|Glycine, 1-(phenylacetyl)-L-prolyl-, ethyl ester|ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]am

规格或纯度：≥98%

英文名称：Noopept

生化机理：DescriptionIC50 Value N/ANoopept (GVS-111) is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.in vitro Nooglutil exhibits pharmacologically significant competition with a selective agonist of AMPA receptors ([G-3H]Ro 48-8587) for the receptor binding sites (with IC50 = 6.4 +/- 0.2 microM), while the competition of noopept for these receptor binding sites was lower by an order of magnitude (IC50 = 80 +/- 5.6 microM) [1]. GVS-111 significantly increased neuronal survival after H(2)O(2)-treatment displaying a dose-dependent neuroprotective activity from 10 nM to 100 microM, and an IC(50) value of 1.21+/-0.07 microM. GVS-111 inhibited the accumulation of intracellular free radicals and lipid peroxidation damage in neurons treated with H(2)O(2) or FeSO(4), sμggesting an antioxidant mechanism of action [2].in vivo N-Phenylacetyl-L-prolylglycine ethyl ester (GVS-111) administered intravenously at a dose of 0.Novel, proline-containing, nootropic and neuroprotective dipeptide drug. Modulates physiological functions such as cognition and anxiety. α-synuclein amyloid toxicity rescued in cell models. Stimulates\xa0NGF and BDNF expression in rat hippocampus.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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PubChem SID：488188513

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488188513

IUPAC Name：ethyl 2-[[(2S)-1-(2-phenylacetyl)pyrrolidine-2-carbonyl]amino]acetate

INCHI：InChI=1S/C17H22N2O4/c1-2-23-16(21)12-18-17(22)14-9-6-10-19(14)15(20)11-13-7-4-3-5-8-13/h3-5,7-8,14H,2,6,9-12H2,1H3,(H,18,22)/t14-/m0/s1

InChi Key：PJNSMUBMSNAEEN-AWEZNQCLSA-N

Canonical SMILES：CCOC(=O)CNC(=O)C1CCCN1C(=O)CC2=CC=CC=C2

Isomeric SMILES：CCOC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CC2=CC=CC=C2

RTECS：MC0814400

PubChem CID：180496

溶解性：solubility in DMSO20 mg/mL, clear

敏感性：对热敏感

比旋光度：-116° (C=0.4,CHCl3)

熔点：96 °C

产品包装