产品名称

英文名称：Cilnidipine

同义词

BCP22689、NCGC00162150-02、UNII-4LNU2SU262、(-)-FRC-8653、AB01274755-01、CILNIDIPINE [MI]、Cilnidipine- Bio-X、J-006141、Q731525、Siscard、HMS2089J07、S85436ZG85、CAS-132203-70-4、STK623341、BDBM50101813、Cilnidipine (JP17/INN)、DB09232、3,5-Pyridinedicarboxylic acid, 1,4、西尼地平

产品性质

CAS编号：132203-70-4

分子式：C27H28N2O7

分子量：492.52

MDL号：MFCD00865853

PubChem编号：5282138

别名：西尼地平

英文别名：BCP22689|NCGC00162150-02|UNII-4LNU2SU262|(-)-FRC-8653|AB01274755-01|CILNIDIPINE [MI]|Cilnidipine- Bio-X|J-006141|Q731525|Siscard|HMS2089J07|S85436ZG85|CAS-132203-70-4|STK623341|BDBM50101813|Cilnidipine (JP17/INN)|DB09232|3,5-Pyridinedicarboxylic acid, 1,4

规格或纯度：≥99%

英文名称：Cilnidipine

生化机理：Cilnidipine is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. Cilnidipine has displayed renal and vascular protective effects and improved baroreflex sensitivity in patients with hypertension. It has also demonstrated neuroprotective effects in a rat focal brain ischemia model by removing free radicals and activating the phosphatidylinositol 3-kinase pathway.Dual L- and N-type Ca 2+ channel blocker (IC 50 values are 100 and 200 nM, respectively). Shows antihypertensive, antinociceptive and neuroprotective effects.

应用：An L-/N-type calcium channel protein inhibitor and blocker

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Cilnidipine是一种钙离子通道抑制剂。It is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels.An L-/N-type calcium channel protein inhibitor and blockerCilnidipine is a calcium channel blocker.It is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply blood vessels.An L-/N-type calcium channel protein inhibitor and blocker

IUPAC Name：3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

INCHI：InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+

InChi Key：KJEBULYHNRNJTE-DHZHZOJOSA-N

Canonical SMILES：CC1=C(C(C(=C(N1)C)C(=O)OCC=CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

Isomeric SMILES：CC1=C(C(C(=C(N1)C)C(=O)OC/C=C/C2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCOC

WGK Germany：3

RTECS：US7975550

PubChem CID：5282138

CAS Registry No.：132203-70-4

Wikipedia：Cilnidipine

ChEMBL Ligand：CHEMBL452076

DrugCentral Ligand：642

溶解性：Soluble in DMSO (> 25 mg/ml), ethanol (20 mg/ml), water (≤ 2 mg/ml), and methanol.

敏感性：对光敏感

熔点：110 °C

象形图：

信号词：Danger

危险声明：H318 Causes serious eye damage

预防措施声明：P280,P264+P265,P305+P354+P338,P317

Merck Index：2275

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装