产品名称

英文名称：Sunitinib Malate

同义词

Sunitinib malate、341031-54-7、Sutent、SU011248 L-malate salt、PHA-290940AD、sunitinib L-malate、Sunitinib malate [USAN]、SU010398、SU-011248 L-malate salt、SU 011248、UNII-LVX8N1UT73、LVX8N1UT73、Sunitinib (Malate)、DTXSID4046492、SU-010398、(Z)-N-(2-(diethylamino)ethy、苹果酸苏尼替尼

产品性质

CAS编号：341031-54-7

分子式：C22H27FN4O2·C4H6O5

分子量：532.56

MDL号：MFCD08282795

PubChem编号：6456015

别名：苹果酸苏尼替尼

英文别名：Sunitinib malate|341031-54-7|Sutent|SU011248 L-malate salt|PHA-290940AD|sunitinib L-malate|Sunitinib malate [USAN]|SU010398|SU-011248 L-malate salt|SU 011248|UNII-LVX8N1UT73|LVX8N1UT73|Sunitinib (Malate)|DTXSID4046492|SU-010398|(Z)-N-(2-(diethylamino)ethy

规格或纯度：≥99%

英文名称：Sunitinib Malate

生化机理：ATP竞争性有效的VEGFR，PDGFRβ和KIT抑制剂（VEGFR -1，-2，-3，PDGFRβ和KIT的ki值分别为2，n，9、17、8和4 nM）。还抑制FLT3，RET和CSF-1R的细胞受体磷酸化。在多种异种移植模型中表现出抗血管生成和抗肿瘤活性。

法律信息：Sold for only research purposes

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.苹果酸舒尼替尼属于多靶点酪氨酸激酶抑制剂。Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit.

IUPAC Name：N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide;(2S)-2-hydroxybutanedioic acid

INCHI：InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChi Key：LBWFXVZLPYTWQI-IPOVEDGCSA-N

Canonical SMILES：CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O

Isomeric SMILES：CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\2/C3=C(C=CC(=C3)F)NC2=O)C.C([C@@H](C(=O)O)O)C(=O)O

WGK Germany：2

PubChem CID：6456015

溶解性：溶于DMSO, 最高浓度 (mg/mL) 13.31, 最高浓度(mM) 25

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P203,P318,P319

产品包装