产品名称

英文名称：Sertindole

同义词

SERTINDOLE、106516-24-9、SerLect、Serdolect、Sertindol、Lu 23-174、Sertindolum、Sertindol [INN-Spanish]、Sertindolum [INN-Latin]、zerdol、Lu-23-174、1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one、1-(2-{4-[5-chloro-1-(4-fluorop、1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑烷酮

产品性质

CAS编号：106516-24-9

分子式：C24H26ClFN4O

分子量：440.9

MDL号：MFCD00867749

PubChem编号：60149

别名：1-[2-[4-[5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-哌啶基]乙基]-2-咪唑烷酮

英文别名：SERTINDOLE|106516-24-9|SerLect|Serdolect|Sertindol|Lu 23-174|Sertindolum|Sertindol [INN-Spanish]|Sertindolum [INN-Latin]|zerdol|Lu-23-174|1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one|1-(2-{4-[5-chloro-1-(4-fluorop

规格或纯度：95%

英文名称：Sertindole

生化机理：Sertindole readily passes the blood-brain barrier and is metabolized into compounds that show greater affinity for 5-HT2 receptors and less for D2 receptors. It is an effective treatment agent for schizophrenia as it improves cognitive impairment.1 Sertindole also acts as antagonist to human cardiac potassium channel, HERG and produces prolonged QT interval.2 Sertindole is a 5-HT2 serotonin and D2 dopamine receptor antagonist and antipsychotic.

应用：Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍Sertindole是5-HT2A，5-HT2C，D2和αl受体拮抗剂。Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.

ALogP：4.1

IUPAC Name：1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one

INCHI：InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)

InChi Key：GZKLJWGUPQBVJQ-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O

Isomeric SMILES：C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O

WGK Germany：3

RTECS：NJ0621100

PubChem CID：60149

Reaxy-Rn：5364890

DrugBank Ligand：DB06144

CAS Registry No.：106516-24-9

ChEBI：CHEBI9122

Wikipedia：Sertindole

ChEMBL Ligand：CHEMBL12713

BindingDB Ligand：50001786

DrugCentral Ligand：2435

GPCRdb Ligand：sertindole

溶解性：DMSO >10 mg/mL；H2O <2 mg/mL

敏感性：对热敏感

熔点：155°C(lit.)

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH413 May cause long lasting harmful effects to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：8466

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装