产品名称

英文名称：Clarithromycin

同义词

6-O-methyl erythromycin、CLARITHROMYCIN (USP IMPURITY)、CLARITHROMYCIN [INN]、DTXCID40820062、8-Hydroxy-3,4-dihydrocarbstyril、CAS-81103-11-9、Clacee、Bicrolid、Boc-Leu-OH.H2O、CLARITHROMYCIN (USP-RS)、(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimeth、克拉霉素

产品性质

CAS编号：81103-11-9

分子式：C38H69NO13

分子量：747.95

EC号：617-200-4,658-034-2

MDL号：MFCD00865140

PubChem编号：84029

别名：克拉霉素

英文别名：6-O-methyl erythromycin|CLARITHROMYCIN (USP IMPURITY)|CLARITHROMYCIN [INN]|DTXCID40820062|8-Hydroxy-3,4-dihydrocarbstyril|CAS-81103-11-9|Clacee|Bicrolid|Boc-Leu-OH.H2O|CLARITHROMYCIN (USP-RS)|(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimeth

规格或纯度：≥98%

英文名称：Clarithromycin

生化机理：Clarithromycin is a 14-member ring macrolide antibiotic and 6-O-methyl derivative of erythromycin. Clarithromycin has reported bacteriostatic action against gram-positive bacteria and some gram-negative bacteria including anaerobes. Similar to other macrolide antibiotics, this antibiotic is believed to function via binding of the ribosome within the microorganism. Studies have noted that Clarithromycin appears to bind specifically to the 50S ribosomal subunit, thus inhibiting DNA translation and inhibiting bacterial growth. This compound is both a substrate and inhibitor of CYP3A4.Macrolide antibiotic. Interferes with protein synthesis by reversibly binding to the 50S subunit in the bacterial ribosome. Regulates matrix metalloprotease activity. Bacteriostatic and bactericidal effects in vitro and in vivo .

应用：A macrolide antibiotic and protein synthesis inhibitor

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，这些产品最多可以使用一周。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Clarithromycin 是一种大环内酯类抗生素，是CYP3A4抑制剂。A macrolide antibiotic and protein synthesis inhibitorClarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.A macrolide antibiotic and protein synthesis inhibitor

IUPAC Name：(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione

INCHI：InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChi Key：AGOYDEPGAOXOCK-KCBOHYOISA-N

Canonical SMILES：CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

Isomeric SMILES：CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O

WGK Germany：3

RTECS：KF4997000

关联CAS：81103-11-9,116836-41-0

PubChem CID：84029

NSC Number：758704

MeSH Entry Terms：6-O-Methylerythromycin;A 56268;A-56268;A56268;Biaxin;Clarithromycin;TE 031;TE-031;TE031

溶解性：Soluble in ethanol (<1 mg/ml), water (<1 mg/ml), acetone (50 mg/ml), DMSO (18 mg/ml), and methanol.

比旋光度：-92°C

熔点：225°C

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowed

预防措施声明：P501,P264,P270,P330,P301+P317

Merck Index：2339

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

产品包装