产品名称

英文名称：(-)-Epigallocatechin gallate

同义词

EGCG 、 3-O-Gallate、3-没食子酸酯 、 (-)-顺式-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7--三醇 3-没食子酸酯 、 (-)-顺式-3,3′,4′,5,5′,7-六羟基-黄烷-3-没食子酸酯

产品性质

CAS编号：989-51-5

分子式：C22H18O11

分子量：458.37

Beilstein号：17(5)8,506

MDL号：MFCD00075940

PubChem编号：65064

别名：3-没食子酸酯 | (-)-顺式-2-(3,4,5-三羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7--三醇 3-没食子酸酯 | (-)-顺式-3,3′,4′,5,5′,7-六羟基-黄烷-3-没食子酸酯

英文别名：EGCG | 3-O-Gallate

规格或纯度：分析标准品

英文名称：(-)-Epigallocatechin gallate

生化机理：(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚，可抑制细胞增殖并诱导细胞凋亡。 (-)-Epigallocatechin Gallate sulfate 可抑制谷氨酸脱氢酶 1/2 (GDH1/2, GLUD1/2) 的活性。(-)-Epigallocatechin Gallate sulfate 对结直肠癌、髓性白血病、甲状腺癌等多种癌症具有有效的抗癌、抗氧化和抗炎特性。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2

IUPAC Name：[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

INCHI：InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

InChi Key：WMBWREPUVVBILR-WIYYLYMNSA-N

Canonical SMILES：C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Isomeric SMILES：C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

WGK Germany：2

RTECS：KB5200000

PubChem CID：65064

UN Number：3077

Packing Group：III

Reaxy-Rn：67944

溶解性：Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol.

密度：1.9

比旋光度：-175.5 ° (C=1, EtOH)

熔点：212°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH317 May cause an allergic skin reactionH312 Harmful in contact with skinH401 Toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P317,P317,P337+P317

Class：9

Merck Index：3526

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装