产品名称

英文名称：(-)-Epigallocatechin gallate

同义词

EGCG、EPIGALLOCATECHIN GALLATE [INCI]、Epigallocic acid、NCGC00164319-04、EGCG、NCGC00164319-01、UNII-BQM438CTEL、(-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate)、SPECTRUM210239、Tox21_303457、S、3-没食子酸酯

产品性质

CAS编号：989-51-5

分子式：C22H18O11

分子量：458.37

Beilstein号：17(5)8,506

MDL号：MFCD00075940

PubChem编号：65064

别名：3-没食子酸酯

英文别名：EGCG|EPIGALLOCATECHIN GALLATE [INCI]|Epigallocic acid|NCGC00164319-04|EGCG|NCGC00164319-01|UNII-BQM438CTEL|(-)-Epigallocatechin gallate (85% (-)-epigallocatechin gallate, 10% (-)-epigallocatechin, 5% (-)- epicatechin gallate)|SPECTRUM210239|Tox21_303457|S

规格或纯度：98%

英文名称：(-)-Epigallocatechin gallate

生化机理：β-分泌酶（BACE1）抑制剂（IC50 =1.6μM）;抑制淀粉样蛋白的组装。抑制诸如Aβ，α-突触核蛋白和亨廷顿蛋白之类的淀粉样蛋白原纤维的形成。减少三种不同细胞类型中Aβ42诱导的细胞死亡。还抑制谷氨酸脱氢酶。抑制细胞生长并选择性诱导A431和人胰腺癌细胞的凋亡。也是DNMT1抑制剂。

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).An inhibitor of Bcl-2 and NOS2

IUPAC Name：[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate

INCHI：InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1

InChi Key：WMBWREPUVVBILR-WIYYLYMNSA-N

Canonical SMILES：C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

Isomeric SMILES：C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

WGK Germany：2

RTECS：KB5200000

PubChem CID：65064

UN Number：3077

Packing Group：III

Reaxy-Rn：67944

CAS Registry No.：989-51-5

ChEMBL Ligand：CHEMBL297453

Wikipedia：Epigallocatechin_gallate

ChEBI：CHEBI4806

BitterDB Ligand：808

RCSB PDB Ligand：EGG, KDH

Antibiotic DB：1416

溶解性：溶于water, 最高浓度 (mg/mL) 4.58, 最高浓度(mM) 10；溶于DMSO, 最高浓度 (mg/mL) 45.84, 最高浓度(mM) 100

密度：1.9

敏感性：对光敏感

比旋光度：-175.5 ° (C=1, EtOH)

熔点：212°C

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH317 May cause an allergic skin reactionH312 Harmful in contact with skinH401 Toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P264,P270,P272,P333+P313,P362+P364,P391,P330,P264+P265,P301+P317,P317,P337+P317

Class：9

Merck Index：3526

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装