产品名称

英文名称：Tyrphostin 9

同义词

Malonoben、tyrphostin A9、10537-47-0、Tyrphostin 9、2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile、NSC 242557、GCP 5126、ENT 27910、SF 6847、RG-50872、AG 17、Tyrphostin 9AG-17、(3,5-Di-t-butyl-4-hydroxybenzylidene)malononitrile、Tyrphostin 9 (RG-50872, Malon

产品性质

CAS编号：10537-47-0

分子式：C18H22N2O

分子量：282.38

MDL号：MFCD00209853

PubChem编号：5614

英文别名：Malonoben|tyrphostin A9|10537-47-0|Tyrphostin 9|2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile|NSC 242557|GCP 5126|ENT 27910|SF 6847|RG-50872|AG 17|Tyrphostin 9AG-17|(3,5-Di-t-butyl-4-hydroxybenzylidene)malononitrile|Tyrphostin 9 (RG-50872, Malon

规格或纯度：≥98%

英文名称：Tyrphostin 9

生化机理：Tyrphostin A9, a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 inhibited TNF-induced tyrosine phosphorylation of pyk2 without blocking the cells' bactericidal activity. Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor (IC50 = 500 nM). Recent findings sμggest that signaling via PDGF receptor tyrosine kinases is not necessary for the shift of the smooth muscle cells from a contractile to a synthetic phenotype. On the other hand these enzymes apparently carry out important functions in the control of intracellular membrane traffic and cell division.Selective inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase (IC 50 = 1.2 μM). Also inhibits epidermal growth factor (EGF) receptor kinase (IC 50 = 460 μM). Potent uncoupler of oxidative phosphorylation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Tyrphostin A9(AG 17)是51种酪氨酸激酶抑制剂，是线粒体分裂诱导剂。Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells。Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells。

IUPAC Name：2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile

INCHI：InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

InChi Key：MZOPWQKISXCCTP-UHFFFAOYSA-N

Canonical SMILES：CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N

Isomeric SMILES：CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N

WGK Germany：3

RTECS：OO3737000

PubChem CID：5614

溶解性：DMSO 56 mg/mL Water <1 mg/mL Ethanol 56 mg/mL

密度：1.1

折光率：1.56

沸点：~386.8° C at 760 mmHg

熔点：139-140°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH311 Toxic in contact with skinH331 Toxic if inhaled

预防措施声明：P261,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P330,P361+P364,P301+P316,P316

个人防护装备：Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

产品包装