产品名称

英文名称：Pemetrexed disodium hydrate

同义词

357166-30-4、Pemetrexed disodium hydrate、Pemetrexed disodium hemipentahydrate、Pemetrexed disodium 2.5 hydrate、Pemetrexed sodium hydrate (245)、UNII-F4GSH45R4C、F4GSH45R4C、Pemetrexed disodium hemipenta hydrate、LY-231514 Disodium Hydrate、Pemetrexed sodium hy、培美曲塞二钠水合物

产品性质

CAS编号：357166-30-4

分子式：C20H21N5O6·5/2H2O·2Na

分子量：516.42

EC号：604-733-2,814-356-7

PubChem编号：135564527

别名：培美曲塞二钠水合物

英文别名：357166-30-4|Pemetrexed disodium hydrate|Pemetrexed disodium hemipentahydrate|Pemetrexed disodium 2.5 hydrate|Pemetrexed sodium hydrate (245)|UNII-F4GSH45R4C|F4GSH45R4C|Pemetrexed disodium hemipenta hydrate|LY-231514 Disodium Hydrate|Pemetrexed sodium hy

规格或纯度：99%

英文名称：Pemetrexed disodium hydrate

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Pemetrexed Disodium Hydrate 是一种新型抗叶酸剂和抗代谢物质，作用于TS，DHFR 和 GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

IUPAC Name：tetrasodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate;pentahydrate

INCHI：InChI=1S/2C20H21N5O6.4Na.5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h2*1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;;;5*1H2/q;;4*+1;;;;;/p-4/t2*13-;;;;;;;;;/m00........./s1

InChi Key：ZCTCZKWJFTYNMZ-WKUCUCPSSA-J

Canonical SMILES：C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]

Isomeric SMILES：C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Na+].[Na+].[Na+].[Na+]

关联CAS：357166-30-4,150399-23-8

PubChem CID：135564527

MeSH Entry Terms：231,514, LY;231514, LY;ALIMTA;Disodium, Pemetrexed;LY 231,514;LY 231514;LY-231,514;LY-231514;LY231514;MTA;N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid;pemetrexed;pemetrexed disodium

敏感性：对湿度敏感

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P304+P340,P403+P233,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

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