产品名称

英文名称：LY-411575

同义词

209984-57-6、LY-411575、LY411575、LY 411575、(S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide、CHEMBL392068、CHEBI87359、n2-[(2s)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-n1-[(7s)-5-

产品性质

CAS编号：209984-57-6

分子式：C26H23F2N3O4

分子量：479.48

MDL号：MFCD09832551

PubChem编号：10435235

英文别名：209984-57-6|LY-411575|LY411575|LY 411575|(S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide|CHEMBL392068|CHEBI87359|n2-[(2s)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-n1-[(7s)-5-

规格或纯度：≥98%

英文名称：LY-411575

生化机理：LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

应用：A potent γ-secretase inhibitor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：LY411575是γ-secretase抑制剂，基于膜和细胞的实验IC50分别为0.078 nM/0.082 nM，还能抑制Notch clevage，IC50为0.39 nM。A potent γ-secretase inhibitorLY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells.A potent γ-secretase inhibitor

IUPAC Name：(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

INCHI：InChI=1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1

InChi Key：ULSSJYNJIZWPSB-CVRXJBIPSA-N

Canonical SMILES：CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O

Isomeric SMILES：C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O

WGK Germany：3

PubChem CID：10435235

溶解性：DMSO

密度：1.4

沸点：~836.0 °C at 760 mmHg

熔点：328.47°C

产品包装