产品名称

英文名称：PIK-93

同义词

PIK-93、593960-11-3、PIK 93、N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide、PIK93、N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide、CHEMBL1229535、N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFA、N-(5-(4-氯-3-(N-(2-羟乙基)氨磺酰基)苯基)-4-甲基噻唑-2-基)乙酰胺

产品性质

CAS编号：593960-11-3

分子式：C14H16ClN3O4S2

分子量：389.88

PubChem编号：6852167

别名：N-(5-(4-氯-3-(N-(2-羟乙基)氨磺酰基)苯基)-4-甲基噻唑-2-基)乙酰胺

英文别名：PIK-93|593960-11-3|PIK 93|N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide|PIK93|N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide|CHEMBL1229535|N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFA

规格或纯度：≥96%

英文名称：PIK-93

生化机理：PIK93 is also known as N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide. It inhibits poliovirus (PV) and coxsackievirus B3 (CVB3) viral RNA production and virus replication. PIK93 also prevents translation mediated by internal ribosome entry site (IRES). PIK-93 inhibits of replication of enterovirus including polio and hepatitis C. PIK93 is a potent, selective, ATP competitive and reversible inhibitor of PI3Kγ and PI4KIIIβ (IC50 = 16 nM and 19 nM, respectively). Also PIK93 moderately inhibits other members of the family including p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC50 = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 μM, respectively). PIK93 blocks ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

产品介绍：PIK-93 是一种合成的，有效的 PI4KIIIβ 抑制剂，IC50 值为 19 nM，同时可抑制 PI3Kγ和 PI3Kα 的活性，IC50 值分别为 16 nM 和 39 nM。PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively.Product ApplicationPIK93 has been used to examine if the accumulation of SNX27–retromer cargoes in FAM21 (family with sequence similarity 21) depleted cells is caused by an elevation of phosphatidylinositol 4-phosphate [PI(4)P] levels at the Golgi.

IUPAC Name：N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide

INCHI：InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)

InChi Key：JFVNFXCESCXMBC-UHFFFAOYSA-N

Canonical SMILES：CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO

Isomeric SMILES：CC1=C(SC(=N1)NC(=O)C)C2=CC(=C(C=C2)Cl)S(=O)(=O)NCCO

WGK Germany：3

PubChem CID：6852167

CAS Registry No.：593960-11-3

DrugBank Ligand：DB06836

ChEMBL Ligand：CHEMBL1229535

RCSB PDB Ligand：93, 093

溶解性：溶于DMSO, 最高浓度 (mg/mL) 38.99, 最高浓度(mM) 100

敏感性：对光线敏感

产品包装