产品名称

英文名称：Veliparib

同义词

ABT-888、BRD-K87142802-001-02-7、Q7919041、2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide、HY-10129、1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-、BDBM209932、NCGC00250404-01、A24888、ABT888 (free base)、Veliparib (ABT-888 hydro、PARP抑制剂

产品性质

CAS编号：912444-00-9

分子式：C13H16N4O

分子量：244.3

PubChem编号：11960529

别名：PARP抑制剂

英文别名：ABT-888|BRD-K87142802-001-02-7|Q7919041|2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide|HY-10129|1H-Benzimidazole-4-carboxamide, 2-((2R)-2-methyl-2-pyrrolidinyl)-|BDBM209932|NCGC00250404-01|A24888|ABT888 (free base)|Veliparib (ABT-888 hydro

规格或纯度：≥99%

英文名称：Veliparib

生化机理：Veliparib is a potent inhibitor of both PARP-1 and PARP-2 by [3H]NAD+ with Kis of 5.2 and 2.9 nmol/L, respectively.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition.A potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agentsVeliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition.A potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents

ALogP：0.5

IUPAC Name：2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide

INCHI：InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1

InChi Key：JNAHVYVRKWKWKQ-CYBMUJFWSA-N

Canonical SMILES：CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N

Isomeric SMILES：C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N

PubChem CID：11960529

CAS Registry No.：912444-00-9

ChEMBL Ligand：CHEMBL506871

DrugBank Ligand：DB07232

Wikipedia：Veliparib

RCSB PDB Ligand：78P

溶解性：DMSO ≥45mg/mL Water <1.2mg/mL Ethanol <1.2.mg/mL

象形图：

信号词：Warning

危险声明：H341 Suspected of causing genetic defectsH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P281,P270,P330,P203,P301+P317,P318,P319

产品包装