产品名称

英文名称：NVP-AUY922

同义词

Luminespib、747412-49-3、NVP-AUY922、AUY922、VER-52296、AUY-922、5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide、Luminespib (NVP-AUY922)、AUY922 (NVP-AUY922)、Luminespib (AUY-922 )、VER 52296、NVP-AUY 922、C6V1DAR5EB

产品性质

CAS编号：747412-49-3

分子式：C26H31N3O5

分子量：465.54

PubChem编号：135539077

英文别名：Luminespib|747412-49-3|NVP-AUY922|AUY922|VER-52296|AUY-922|5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide|Luminespib (NVP-AUY922)|AUY922 (NVP-AUY922)|Luminespib (AUY-922 )|VER 52296|NVP-AUY 922|C6V1DAR5EB

规格或纯度：≥98%

英文名称：NVP-AUY922

生化机理：NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of Hsp90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to Hsp90. NVP-AUY922 causes p23 dissociation from the Hsp90 complex and can then recruit HSP70 to the Hsp90 complex. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of Hsp90 to client proteins and setting them up as targets for degradation by the proteasome.NVP-AUY922 can influence cell growth by affecting mutiple signaling pathways.

应用：A highly potent HSP90 inhibitor to HSP90α and HSP90β

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：25mg、10mg卖完停产，不再备货

产品介绍：Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，其对HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何HSP90配体均可紧密结合。Phase 2。A highly potent HSP90 inhibitor to HSP90α and HSP90βLuminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.A highly potent HSP90 inhibitor to HSP90α and HSP90β

ALogP：3.5

IUPAC Name：5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide

INCHI：InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)

InChi Key：NDAZATDQFDPQBD-UHFFFAOYSA-N

Canonical SMILES：CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C

Isomeric SMILES：CCNC(=O)C1=NOC(=C1C2=CC=C(C=C2)CN3CCOCC3)C4=CC(=C(C=C4O)O)C(C)C

关联CAS：747412-49-3

PubChem CID：135539077

MeSH Entry Terms：5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethylphenyl)isoxazole-3-carboxylic acid ethylamide;5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide;AUY922;luminespib;NVP-AUY922;VER 52296;VER-52296;V

溶解性：Soluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble).

产品包装