产品名称

英文名称：Shikonin

同义词

5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione 、 Shikonin S 、 (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone 、 2-(2-methoxyethoxyl)ethyl 4-methylbenzenesulfonate 、 shikonin 、 (R)-5,8-Dihydroxy-2-(1-hydro、(±)-Alkannin 、 (±)-Shikalkin 、 (±)-Shikonin 、 (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone 、 紫草宁 、 (±)-5,8-二羟基-2-(1-羟基-4-甲基-3-戊烯基)-1,4-萘醌 、 (±)-紫草宁 、 (±)-紫草素

产品性质

CAS编号：517-89-5

分子式：C16H16O5

分子量：288.3

PubChem编号：479503

别名：(±)-Alkannin | (±)-Shikalkin | (±)-Shikonin | (±)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone | 紫草宁 | (±)-5,8-二羟基-2-(1-羟基-4-甲基-3-戊烯基)-1,4-萘醌 | (±)-紫草宁 | (±)-紫草素

英文别名：5,8-Dihydroxy-2-[(1R)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione | Shikonin S | (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone | 2-(2-methoxyethoxyl)ethyl 4-methylbenzenesulfonate | shikonin | (R)-5,8-Dihydroxy-2-(1-hydro

规格或纯度：分析标准品，≥98%

英文名称：Shikonin

生化机理：Shikonin is a naturally occurring active chemical found in the root of Lithospermum erythrorhizon and used as a Chinese herb. The compound is a naphthoquinone derivative and has been shown to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Angiogenesis studies have shown that Shikonin can inhibit proliferation and migration of endothelial cells, block integrin αvβ3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-inuced angiogenesis in mice. Shikonin can down-regulate protein and mRNA expression of CKR-5 (CCR5), a primary HIV-1 coreceptor, in macrophages in HIV studies. Shikonin is an inhibitor of PKM2.

应用：A naphthoquinone derivative with angiogenesis inhibitor properties.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：紫草素是从紫草根中提取的一种主要的植物化学成分。它是一种天然蒽醌衍生物。应用紫草素已被用于增强吉非替尼对野生型肺癌细胞酪氨酸激酶受体表皮生长因子受体(EGFR)的抗肿瘤活性；用作肾脏需氧糖病的抑制剂；作为抗炎剂，以测试其改善脂多糖(LPS)诱导的心功能障碍的作用；刺激骨髓源性巨噬细胞(BMDM)，检测干扰素调节因子1对细胞死亡的影响。A naphthoquinone derivative with angiogenesis inhibitor properties. Shikonin is a major phytochemical compound extracted from the roots of Lithospermum erythrorhizon. It is a natural anthraquinone derivative.

IUPAC Name：5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione

INCHI：InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3/t10-/m1/s1

InChi Key：NEZONWMXZKDMKF-SNVBAGLBSA-N

Canonical SMILES：CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

Isomeric SMILES：CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C

PubChem CID：479503

溶解性：溶于DMSO；Ethanol

密度：1.373

象形图：

信号词：Warning

危险声明：H412 Harmful to aquatic life with long lasting effectsH302 Harmful if swallowed

预防措施声明：P273,P501,P264,P270,P301+P312+P330

产品包装