产品名称

英文名称：LDN-193189

同义词

1062368-24-4、LDN193189、LDN-193189、4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline、LDN 193189、4-[6-(4-Piperazin-1-Ylphenyl)pyrazolo[1,5-A]pyrimidin-3-Yl]quinoline、LDN193189 free base、DM-3189、W69H5YQU9O、CHEMBL513147、LDN193189 (GMP)、4-

产品性质

CAS编号：1062368-24-4

分子式：C25H22N6

分子量：479.4

PubChem编号：25195294

英文别名：1062368-24-4|LDN193189|LDN-193189|4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline|LDN 193189|4-[6-(4-Piperazin-1-Ylphenyl)pyrazolo[1,5-A]pyrimidin-3-Yl]quinoline|LDN193189 free base|DM-3189|W69H5YQU9O|CHEMBL513147|LDN193189 (GMP)|4-

规格或纯度：≥98%

英文名称：LDN-193189

生化机理：LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50 5 nM), ALK3 (IC50 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：LDN-193189是一种选择性的BMP信号通路抑制剂，抑制BMP I型受体ALK2和ALK3的转录活性，IC50分别为5 nM和30 nM，作用于BMP比作用于TGF-β选择性高200倍。LDN193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.

IUPAC Name：4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

INCHI：InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2

InChi Key：CDOVNWNANFFLFJ-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3

Isomeric SMILES：C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3

PubChem CID：25195294

溶解性：DMSO 0.01 mg/mL (<1 mM); Water 0.01 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)

产品包装