产品名称

英文名称：PF-00562271

同义词

AC-27465、AM20090125、SCHEMBL20471937、GTPL7332、METHANESULFONAMIDE, N-(3-(((2-((2,3-DIHYDRO-2-OXO-1H-INDOL-5-YL)AMINO)-5-(TRIFLUOROMETHYL)-4-PYRIMIDINYL)AMINO)METHYL)-2-PYRIDINYL)-N-METHYL-, BENZENESULFONATE、PF-562271 benzenesulfonate、N-methyl-N-{3-[({2-[(2-、PF 562271 苯磺酸盐

产品性质

CAS编号：939791-38-5

分子式：C21H20F3N7O3S·C6H6O3S

分子量：665.66

PubChem编号：16118986

别名：PF 562271 苯磺酸盐

英文别名：AC-27465|AM20090125|SCHEMBL20471937|GTPL7332|METHANESULFONAMIDE, N-(3-(((2-((2,3-DIHYDRO-2-OXO-1H-INDOL-5-YL)AMINO)-5-(TRIFLUOROMETHYL)-4-PYRIMIDINYL)AMINO)METHYL)-2-PYRIDINYL)-N-METHYL-, BENZENESULFONATE|PF-562271 benzenesulfonate|N-methyl-N-{3-[({2-[(2-

规格或纯度：≥97%

英文名称：PF-00562271

生化机理：PF-562271 displays selective inhibitory effects on FAK (IC50 of 1.5 nM) and Pyk2(IC50 of 14 nM) tyrosine kinase activity. In cell-based assays, PF-562271 is shown to be more selective for FAK compared to other kinase targets (IC50 of 5 nM). PF-562271 results in a dose-dependent cell proliferation inhibition in FAK WT (IC50 of 3.3 μM), FAK?/? (IC50 of 2.08 μM) and FAK kinase-deficient (KD) cells (IC50 of 2.01 μM), in 2 dimensional (2D) cultures.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：PF-00562271是PF-562271的苯磺酸盐，是一种有效的，ATP竞争性，可逆的FAK抑制剂，IC50为1.5 nM，作用于Pyk2比作用于FAK效果低10倍左右，比作用于其他蛋白激酶（除了一些CDKs）选择性高100倍以上。A potent inhibitor of focal adhesion kinase (FAK) and Pyk2.PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.A potent inhibitor of focal adhesion kinase (FAK) and Pyk2.

IUPAC Name：benzenesulfonic acid;N-methyl-N-[3-[[[2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide

INCHI：InChI=1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;7-10(8,9)6-4-2-1-3-5-6/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30);1-5H,(H,7,8,9)

InChi Key：LKLWTLXTOVZFAE-UHFFFAOYSA-N

Canonical SMILES：CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

Isomeric SMILES：CN(C1=C(C=CC=N1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C.C1=CC=C(C=C1)S(=O)(=O)O

PubChem CID：16118986

溶解性：Soluble in DMSO (14 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

产品包装