产品名称

英文名称：HMN-214

同义词

HMN-214、173529-46-9、IVX-214、(E)-4-(2-(N-((4-methoxyphenyl)sulfonyl)acetamido)styryl)pyridine 1-oxide、94E9UR0RFR、HMN214、(E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide、(E)-4-[2-[2-[N-acetyl-N-[(4-methoxyphenyl)sulfo

产品性质

CAS编号：173529-46-9

分子式：C22H20N2O5S

分子量：424.48

PubChem编号：9888590

英文别名：HMN-214|173529-46-9|IVX-214|(E)-4-(2-(N-((4-methoxyphenyl)sulfonyl)acetamido)styryl)pyridine 1-oxide|94E9UR0RFR|HMN214|(E)-4-(2-(2-(N-Acetyl-N-((p-methoxyphenyl)sulfonyl)amino)phenyl)ethenyl)pyridine 1-oxide|(E)-4-[2-[2-[N-acetyl-N-[(4-methoxyphenyl)sulfo

规格或纯度：≥98%

英文名称：HMN-214

生化机理：HMN-214 (IVX-214) is a potent inhibitor of Polo-like kinase (Plk) with IC50 of 118 nM. HMN-214 shows potent and broad-spectrum anti-tumor activity against various cancer cells, including HeLa, PC-3, DU-145, MIAPaCa-2, U937, MCF-7, A549, and WiDr, with a mean IC50 value of 118 nM. HMN-176 is also cytotoxic to drμg-resistant human and murine cell lines, including P388/CDDP, P388/VCR, K2/CDDP, and K2/VP-16, with IC50 values ranging from 143 nM–265 nM. In HeLa cells, HMN-176 (3 μM) blocks cell cycle at G2/M phase. HMN-176 (3 μM) down-regulates the expression of the multi-drμg resistance gene (MDR1), due to the disturbance of NF-Y transcription factor binding to the MDR1 promoter. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formation of Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：HMN-214(IVX214)是PLK1抑制剂，平均IC50为0.12 μM。A potent inhibitor of Polo-like kinase and a broad-spectrum anti-tumor agentHMN-214 is a prodrug of HMN-176, which alters the cellular spatial orientation of Plk1.A potent inhibitor of Polo-like kinase and a broad-spectrum anti-tumor agent

IUPAC Name：N-(4-methoxyphenyl)sulfonyl-N-[2-[(E)-2-(1-oxidopyridin-1-ium-4-yl)ethenyl]phenyl]acetamide

INCHI：InChI=1S/C22H20N2O5S/c1-17(25)24(30(27,28)21-11-9-20(29-2)10-12-21)22-6-4-3-5-19(22)8-7-18-13-15-23(26)16-14-18/h3-16H,1-2H3/b8-7+

InChi Key：OCKHRKSTDPOHEN-BQYQJAHWSA-N

Canonical SMILES：CC(=O)N(C1=CC=CC=C1C=CC2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC

Isomeric SMILES：CC(=O)N(C1=CC=CC=C1/C=C/C2=CC=[N+](C=C2)[O-])S(=O)(=O)C3=CC=C(C=C3)OC

PubChem CID：9888590

溶解性：DMSO 12 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装