产品名称

英文名称：Vilanterol

同义词

YAA35107、AKOS032950047、GW 642444X、Vilanterol (USAN)、VILANTEROL [WHO-DD]、AMY6916、GW642444、028LZY775B、NSC114767、4-[(1R)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol、DAFYYTQWSAWIGS-DEOSSOPVSA-N、Vilanterol、1,、维兰特罗

产品性质

CAS编号：503068-34-6

分子式：C24H33Cl2NO5

分子量：486.43

PubChem编号：10184665

别名：维兰特罗

英文别名：YAA35107|AKOS032950047|GW 642444X|Vilanterol (USAN)|VILANTEROL [WHO-DD]|AMY6916|GW642444|028LZY775B|NSC114767|4-[(1R)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol|DAFYYTQWSAWIGS-DEOSSOPVSA-N|Vilanterol|1,

规格或纯度：≥98%

英文名称：Vilanterol

生化机理：in vitroVilanterol displayed a subnanomolar affinity for the β(2)-AR that was comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol. In cAMP functional activity studies, vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR, but a significantly improved selectivity profile than formoterol and indacaterol. Vilanterolalso showed a level of intrinsic efficacy that was comparable to indacaterol but significantly greater than that of salmeterol。 in vivo The combination of FF/VI at a strength of 100/25 μg significantly (p < 0.001) improved wm FEV1 (173 ml) and troμgh FEV1 (115 ml) vs. placebo. Similar effects were observed with FF/VI 50/25 μg. VI 25 μg over 24 weeks improved lung function vs. placebo significantly for wm FEV1 (103 ml, p < 0.001) and troμgh FEV1 (67 ml, p = 0.017)

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、50mg、25mg卖完停产，不再备货

产品介绍：Vilanterol (GW642444; GW 642444X)是吸入型长效β2激动剂。Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-acting β(2) agonist with inherent 24-h activity under development as a once-daily combination therapy with an inhaled corticosteroid for COPD and asthma.

IUPAC Name：4-[(1R)-2-[6-[2-[(2,6-dichlorophenyl)methoxy]ethoxy]hexylamino]-1-hydroxyethyl]-2-(hydroxymethyl)phenol

INCHI：InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1

InChi Key：DAFYYTQWSAWIGS-DEOSSOPVSA-N

Canonical SMILES：C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)Cl

Isomeric SMILES：C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNC[C@@H](C2=CC(=C(C=C2)O)CO)O)Cl

PubChem CID：10184665

ChEMBL Ligand：CHEMBL1198857

CAS Registry No.：503068-34-6

Wikipedia：Vilanterol

DrugCentral Ligand：4799

GPCRdb Ligand：vilanterol

溶解性：25°C DMSO

象形图：

信号词：Danger

危险声明：H411 Toxic to aquatic life with long lasting effectsH370 Causes damage to organs

预防措施声明：P273,P321,P405,P501,P264,P260,P270,P391,P308+P316

产品包装