产品名称

英文名称：NP118809

同义词

41332-24-5、NP118809、1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone、NP-118809、Z-160、1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one、Z160、Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-、MK-6721、TX3R141LEP、NMED-160、39-1B4

产品性质

CAS编号：41332-24-5

分子式：C32H32N2O

分子量：460.61

PubChem编号：4988454

英文别名：41332-24-5|NP118809|1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone|NP-118809|Z-160|1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one|Z160|Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-|MK-6721|TX3R141LEP|NMED-160|39-1B4|

规格或纯度：≥98%

英文名称：NP118809

生化机理：In VitroNP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM. In VivoNP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍 NP118809 是一种有效的 N 型钙通道 (N-type calcium channel) 阻滞剂，IC50 值为 0.11 μM；同时可较弱地抑制 L 型钙通道 (L-type calcium channel)，IC50 值为 12.2 μM。

ALogP：6.1

IUPAC Name：1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one

INCHI：InChI=1S/C32H32N2O/c35-31(25-30(26-13-5-1-6-14-26)27-15-7-2-8-16-27)33-21-23-34(24-22-33)32(28-17-9-3-10-18-28)29-19-11-4-12-20-29/h1-20,30,32H,21-25H2

InChi Key：VCPMZDWBEWTGNW-UHFFFAOYSA-N

Canonical SMILES：C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5

Isomeric SMILES：C1CN(CCN1C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)CC(C4=CC=CC=C4)C5=CC=CC=C5

PubChem CID：4988454

CAS Registry No.：41332-24-5

ChEMBL Ligand：CHEMBL604710

溶解性：insoluble in H2O; insoluble in EtOH; ≥63.4 mg/mL in DMSO

产品包装