产品名称

英文名称：Dinaciclib (SCH727965)

同义词

Dinaciclib、779353-01-4、SCH727965、Dinaciclib (SCH727965)、SCH 727965、SCH-727965、MK-7965、(S)-3-(((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide、(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]py

产品性质

CAS编号：779353-01-4

分子式：C21H28N6O2

分子量：396.49

PubChem编号：46926350

英文别名：Dinaciclib|779353-01-4|SCH727965|Dinaciclib (SCH727965)|SCH 727965|SCH-727965|MK-7965|(S)-3-(((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methyl)pyridine 1-oxide|(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]py

规格或纯度：≥98%

英文名称：Dinaciclib (SCH727965)

生化机理：Dinaciclib(SCH 727965 ) is a pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib(SCH 727965 ) selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis.Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC 50 values\xa0are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor\xa0that blocks thymidine incorporation in A2780 ova

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Dinaciclib (SCH727965)是CDK抑制剂，对CDK2，CDK5，CDK1和CDK9的IC50分别为1 nM，1 nM，3 nM和4 nM。A novel and potent cyclin-dependent kinase inhibitor for Cdk2, Cdk5, Cdk1, and Cdk9Dinaciclib (SCH727965) is a novel and potent CDK inhibitor for CDK2, CDK5, CDK1 and CDK9 with IC50 of 1 nM, 1 nM, 3 nM and 4 nM in cell-free assays, respectively. It also blocks thymidine (dThd) DNA incorporation.A novel and potent cyclin-dependent kinase inhibitor for Cdk2, Cdk5, Cdk1, and Cdk9

ALogP：1.9

IUPAC Name：2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol

INCHI：InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1

InChi Key：PIMQWRZWLQKKBJ-SFHVURJKSA-N

Canonical SMILES：CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCCC4CCO

Isomeric SMILES：CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO

PubChem CID：46926350

Wikipedia：Dinaciclib

CAS Registry No.：779353-01-4

ChEMBL Ligand：CHEMBL2103840

溶解性：DMSO ≥ 56 mg/mL

熔点：107-111°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH372 Causes damage to organs through prolonged or repeated exposureH340 May cause genetic defects

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P281,P270,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317,P319

产品包装