产品名称

英文名称：Cabozantinib malate (XL184)

同义词

Cabozantinib S-malate、1140909-48-3、Cabozantinib malate、cabozantinib (S)-malate、Cabometyx、Cabozantinib malate (XL184)、Cabozantinib (S-malate)、XL184、Cometriq、UNII-DR7ST46X58、BMS907351、Cabozantinib s-malate [USAN]、cabozantinib L-malate、DR7ST46X58、CHEBI72319、苹果酸卡博替尼

产品性质

CAS编号：1140909-48-3

分子式：C28H24FN3O5·C4H6O5

分子量：635.59

PubChem编号：25102846

别名：苹果酸卡博替尼

英文别名：Cabozantinib S-malate|1140909-48-3|Cabozantinib malate|cabozantinib (S)-malate|Cabometyx|Cabozantinib malate (XL184)|Cabozantinib (S-malate)|XL184|Cometriq|UNII-DR7ST46X58|BMS907351|Cabozantinib s-malate [USAN]|cabozantinib L-malate|DR7ST46X58|CHEBI72319

规格或纯度：≥99%

英文名称：Cabozantinib malate (XL184)

生化机理：Cabozantinib S malate (XL184 BMS 907351) is a potent VEGFR2 inhibitor with IC50 of 0 035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：10mg卖完停产，不再备货

产品介绍：Cabozantinib malate (XL184)是Cabozantinib的苹果酸盐，是有效的VEGFR2抑制剂，IC50为0.035 nM，也抑制c-Met， Ret， Kit， Flt-1/3/4， Tie2和AXL，IC50分别为1.3 nM， 4 nM， 4.6 nM， 12 nM/11.3 nM/6 nM， 14.3 nM和7 nM。Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively

IUPAC Name：1-N-[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-1-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide;(2S)-2-hydroxybutanedioic acid

INCHI：InChI=1S/C28H24FN3O5.C4H6O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18;5-2(4(8)9)1-3(6)7/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34);2,5H,1H2,(H,6,7)(H,8,9)/t;2-/m.0/s1

InChi Key：HFCFMRYTXDINDK-WNQIDUERSA-N

Canonical SMILES：COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O

Isomeric SMILES：COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C([C@@H](C(=O)O)O)C(=O)O

PubChem CID：25102846

溶解性：DMSO 127 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P203,P264+P265,P301+P317,P318,P337+P317,P332+P317,P319

产品包装