产品名称

英文名称：Ponesimod

同义词

Ponesimod、854107-55-4、ACT-128800、Ponvory、5G7AKV2MKP、CHEMBL1096146、ACT128800、(Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one、(2Z,5Z)-5-(3-Chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-

产品性质

CAS编号：854107-55-4

分子式：C23H25ClN2O4S

分子量：460.974

PubChem编号：11363176

英文别名：Ponesimod|854107-55-4|ACT-128800|Ponvory|5G7AKV2MKP|CHEMBL1096146|ACT128800|(Z)-5-((Z)-3-chloro-4-((R)-2,3-dihydroxypropoxy)benzylidene)-2-(propylimino)-3-(o-tolyl)thiazolidin-4-one|(2Z,5Z)-5-(3-Chloro-4-((2R)-2,3-dihydroxypropoxy)phenylmethylidene)-3-(2-

规格或纯度：97%

英文名称：Ponesimod

生化机理：庞西莫德是鞘氨醇-1-磷酸受体的有效激动剂。\ xa0（S1P 1 / EDG-1;对于S1P 1 -S1P 5而言，IC 50 s = 6，分别大于10,000、2,068、1,956和142 nM。放射性配体结合测定）。在GTPγS分析中选择性激活S1P 1（EC 50 s = 5。

储存温度：-20°C储存

运输条件：超低温冰袋运输

ALogP：4.6

IUPAC Name：(5Z)-5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylidene]-3-(2-methylphenyl)-2-propylimino-1,3-thiazolidin-4-one

INCHI：InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23?/t17-/m1/s1

InChi Key：LPAUOXUZGSBGDU-ULCCENQXSA-N

Canonical SMILES：CCCN=C1N(C(=O)C(=CC2=CC(=C(C=C2)OCC(CO)O)Cl)S1)C3=CC=CC=C3C

Isomeric SMILES：CCCN=C1N(C(=O)/C(=C/C2=CC(=C(C=C2)OC[C@@H](CO)O)Cl)/S1)C3=CC=CC=C3C

PubChem CID：11363176

ChEMBL Ligand：CHEMBL1096146

CAS Registry No.：854107-55-4

DrugCentral Ligand：5446

GPCRdb Ligand：ponesimod

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH411 Toxic to aquatic life with long lasting effectsH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH360 May damage fertility or the unborn childH360D May damage the unborn child

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P391,P330,P203,P264+P265,P301+P317,P318,P317,P337+P317,P332+P317,P319

产品包装