产品名称

英文名称：GDC-0349

同义词

GDC-0349、1207360-89-1、(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea、CHEMBL2331680、GDC 0349、RG-7603、579255I6O9、GDC0349、RGJOJUGRHPQXGF-INIZCTEOSA-N、UNII-579255I6O9、1-ethyl-3-[4-[4-[(3S)-3-

产品性质

CAS编号：1207360-89-1

分子式：C24H32N6O3

分子量：452.55

PubChem编号：59239165

英文别名：GDC-0349|1207360-89-1|(S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea|CHEMBL2331680|GDC 0349|RG-7603|579255I6O9|GDC0349|RGJOJUGRHPQXGF-INIZCTEOSA-N|UNII-579255I6O9|1-ethyl-3-[4-[4-[(3S)-3-

规格或纯度：≥99%

英文名称：GDC-0349

生化机理：GDC-0349 is a potent mTOR inhibitor. GDC-0349 has entered in a phase I clinical trials in the treatment of Solid Tumors or Non Hodgkin's Lymphoma.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍GDC-0349 是一种有效的，ATP竞争性的选择性 mTOR 抑制剂，Ki 值为 3.8 nM。GDC-0349 抑制 mTORC1 和 mTORC2 复合体。Product descriptionGDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

IUPAC Name：1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea

INCHI：InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1

InChi Key：RGJOJUGRHPQXGF-INIZCTEOSA-N

Canonical SMILES：CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C

Isomeric SMILES：CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C

PubChem CID：59239165

溶解性：DMSO 91 mg/mL Water <1 mg/mL Ethanol 6 mg/mL

产品包装