产品名称

英文名称：BMN 673

同义词

Talazoparib、1207456-01-6、BMN-673、BMN 673、BMN673、Talazoparib (BMN 673)、Talzenna、(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one、LT-673、UNII-9QHX048FRV、9QHX048FRV、Talazoparib(BMN-673

产品性质

CAS编号：1207456-01-6

分子式：C19H14F2N6O

分子量：380.35

EC号：806-564-1,815-271-8

PubChem编号：135565082

英文别名：Talazoparib|1207456-01-6|BMN-673|BMN 673|BMN673|Talazoparib (BMN 673)|Talzenna|(8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one|LT-673|UNII-9QHX048FRV|9QHX048FRV|Talazoparib(BMN-673

规格或纯度：≥98%

英文名称：BMN 673

生化机理：BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. PARP inhibitor BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg卖完停产，不再备货

产品介绍：BMN 673是一种新型的PARP抑制剂，IC50为0.58 nM，也有效抑制PARP-2，但不抑制PARG，对PTEN突变型高度敏感。BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation.

ALogP：2.3

IUPAC Name：(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one

INCHI：InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1

InChi Key：HWGQMRYQVZSGDQ-HZPDHXFCSA-N

Canonical SMILES：CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F

Isomeric SMILES：CN1C(=NC=N1)[C@@H]2[C@H](NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F

关联CAS：1207456-01-6,1373431-65-2

PubChem CID：135565082

MeSH Entry Terms：BMN 673;BMN-673;BMN673;talazoparib;Talzenna

溶解性：DMSO 96 mg/mL Water <1 mg/mL Ethanol 96 mg/mL

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P281,P270,P203,P318,P319

产品包装