产品名称

英文名称：AST-1306 TsOH

同义词

1050500-29-2、Allitinib tosylate、AST-1306 TsOH、AST-6、AST-1306 (TsOH)、N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide;4-methylbenzenesulfonic acid、AST 1306 tosylate、MLS006011282、SCHEMBL230864、CHEMBL4779286、DTXSID30648510、HMS

产品性质

CAS编号：1050500-29-2

分子式：C24H18ClFN4O2·C7H8O3S

分子量：621.08

PubChem编号：25027665

英文别名：1050500-29-2|Allitinib tosylate|AST-1306 TsOH|AST-6|AST-1306 (TsOH)|N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide;4-methylbenzenesulfonic acid|AST 1306 tosylate|MLS006011282|SCHEMBL230864|CHEMBL4779286|DTXSID30648510|HMS

规格或纯度：≥98%

英文名称：AST-1306 TsOH

生化机理：AST-1306 TsOH is a potent(pM) and selective inhibitor of EGFR and ErbB4 (IC50 = 500pM and 800 pM, respectively). AST 1306 blocks phosphorylation of EGFR and also prevents downstream pathways. AST 1306 also dose-dependently inhibits EGF-induced EGFR phosphorylation in the A549 cancer cell line.

应用：A potent and selective inhibitor of EGFR phosphorylation.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：卖完停产，不再备货

产品介绍：AST-1306 TsOH是一种新型，不可逆的EGFR和ErbB2抑制剂，IC50分别为0.5 nM和3 nM，对突变型EGFR T790M/L858R也有效，作用于过表达ErbB2的细胞更有效，作用于ErbB家族比作用于其他激酶选择性高3000倍。A potent and selective inhibitor of EGFR phosphorylation.AST-1306 TsOH is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, also effective in mutation EGFR T790M/L858R, more potent to ErbB2-overexpressing cells, 3000-fold selective for ErbB family than other kinases,A potent and selective inhibitor of EGFR phosphorylation.

IUPAC Name：N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]prop-2-enamide;4-methylbenzenesulfonic acid

INCHI：InChI=1S/C24H18ClFN4O2.C7H8O3S/c1-2-23(31)29-17-6-8-21-19(11-17)24(28-14-27-21)30-18-7-9-22(20(25)12-18)32-13-15-4-3-5-16(26)10-15;1-6-2-4-7(5-3-6)11(8,9)10/h2-12,14H,1,13H2,(H,29,31)(H,27,28,30);2-5H,1H3,(H,8,9,10)

InChi Key：ZMUKJEHWLJBODV-UHFFFAOYSA-N

Canonical SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

Isomeric SMILES：CC1=CC=C(C=C1)S(=O)(=O)O.C=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=C(C=C3)OCC4=CC(=CC=C4)F)Cl

PubChem CID：25027665

溶解性：Soluble in DMSO (124 mg/mL), water (<1 mg/mL), and ethanol (<1 mg/mL).

产品包装