产品名称

英文名称：CO-1686 (AVL-301)

同义词

Rociletinib、1374640-70-6、CO-1686、AVL-301、CNX-419、N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide、Rociletinib (CO-1686)、CO-1686 (AVL-301)、CS-1631、N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2

产品性质

CAS编号：1374640-70-6

分子式：C27H28F3N7O3

分子量：555.55

PubChem编号：57335384

英文别名：Rociletinib|1374640-70-6|CO-1686|AVL-301|CNX-419|N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide|Rociletinib (CO-1686)|CO-1686 (AVL-301)|CS-1631|N-(3-((2-((4-(4-Acetylpiperazin-1-yl)-2

规格或纯度：≥99%

英文名称：CO-1686 (AVL-301)

生化机理：DescriptionIC50 Value 21.5±1.7 nM (EGFRL858R/T790M); 303.3 ± 26.7 nM (EGFRWT) [1]CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M while exhibiting minimal activity towards the wild-type (WT) receptor.in vitro CO-1686 is a potent inhibitor of EGFR L858R/T790M kinase (kinact/Ki = (2.41 ± 0.30) x 105 M-1s-1) and is approximately 22-fold selective over WT EGFR (kinactt/Ki = (1.12 ± 0.14) x 104 M-1s-1). CO-1686 potently inhibited proliferation in the mutant-EGFR NSCLC cellswith GI50 values ranging from 7 - 32 nM. In comparison, the GI50 value for A431 cells, an epidermoid cell line that is driven by amplified WT EGFR(19), was 547 nM. Two cell linesexpressing WT EGFR in the presence of an N- or KRAS mutation (NCI-H1299 and NCI-H358,respectively) were inhibited by CO-1686 at a concentration of 4275 and 1806 nM, respectively [1].

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：50mg、10mg卖完停产，不再备货

产品介绍：CO-1686 (AVL-301)是一种不可逆的，突变选择性的EGFR抑制剂，作用于EGFRL858R/T790M和EGFRWT， Ki分别为21.5 nM和303.3 nM。Phase 2。CO-1686 is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFRL858R/T790M and EGFRWT, respectively. Phase 2.

ALogP：4

IUPAC Name：N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide

INCHI：InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)

InChi Key：HUFOZJXAKZVRNJ-UHFFFAOYSA-N

Canonical SMILES：CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

Isomeric SMILES：CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

PubChem CID：57335384

CAS Registry No.：1374640-70-6

RCSB PDB Ligand：8JC

溶解性：DMSO 100 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

产品包装